| pubmed-article:2819917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2819917 | lifeskim:mentions | umls-concept:C0011892 | lld:lifeskim |
| pubmed-article:2819917 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2819917 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:2819917 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2819917 | lifeskim:mentions | umls-concept:C1868264 | lld:lifeskim |
| pubmed-article:2819917 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2819917 | pubmed:dateCreated | 1987-10-16 | lld:pubmed |
| pubmed-article:2819917 | pubmed:abstractText | The inhibition of basal and forskolin-stimulated platelet adenylate cyclase activity by (-)adrenaline was studied in ten heroin addicts during spontaneous withdrawal. Both basal and forskolin-stimulated enzyme activities were increased during heroin withdrawal and the inhibitory effect induced by (-)adrenaline was potentiated with parallel shifts to the left of the concentration-effect curves. The number of binding sites for [3H](-)adrenaline in platelet membranes was also increased during withdrawal. Treatment with clonidine markedly attenuated the inhibitory effect induced by (-)adrenaline on platelet adenylate cyclase activity. The results indicate that the heroin withdrawal syndrome induces supersensitivity of the platelet alpha 2-adrenoceptor-adenylate cyclase system. | lld:pubmed |
| pubmed-article:2819917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2819917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2819917 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2819917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2819917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2819917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2819917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2819917 | pubmed:issn | 0033-3158 | lld:pubmed |
| pubmed-article:2819917 | pubmed:author | pubmed-author:GutierrezMM | lld:pubmed |
| pubmed-article:2819917 | pubmed:author | pubmed-author:García-Sevill... | lld:pubmed |
| pubmed-article:2819917 | pubmed:author | pubmed-author:UlibarriII | lld:pubmed |
| pubmed-article:2819917 | pubmed:author | pubmed-author:UgedoLL | lld:pubmed |
| pubmed-article:2819917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2819917 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:2819917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2819917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2819917 | pubmed:pagination | 320-3 | lld:pubmed |
| pubmed-article:2819917 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:meshHeading | pubmed-meshheading:2819917-... | lld:pubmed |
| pubmed-article:2819917 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2819917 | pubmed:articleTitle | Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase activity in heroin addicts in abstinence. | lld:pubmed |
| pubmed-article:2819917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2819917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
