| pubmed-article:2819872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C0085416 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C1384115 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C0699857 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:2819872 | lifeskim:mentions | umls-concept:C2348277 | lld:lifeskim |
| pubmed-article:2819872 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:2819872 | pubmed:dateCreated | 1987-10-15 | lld:pubmed |
| pubmed-article:2819872 | pubmed:abstractText | The macrophage cell line RAW 264.7 when activated with Escherichia coli lipopolysaccharide and interferon-gamma synthesized nitrite (NO3-) and nitrate (NO3-). Medium change after the activation showed that L-arginine was the only amino acid essential for this synthesis. D-Arginine would not substitute for L-arginine. Other analogues that could replace L-arginine were L-homoarginine, L-arginine methyl ester, L-arginamide, and the peptide L-arginyl-L-aspartate. L-Argininic acid, L-agmatine, L-ornithine, urea, L-citrulline, and ammonia were among the nonprecursors, while L-canavanine inhibited this L-arginine-derived NO2-/NO3- synthesis. When morpholine was added to the culture medium of the activated RAW 264.7 macrophages, N-nitrosation took place, generating N-nitrosomorpholine. GC/MS experiments using L-[guanido-15N2]arginine established that the NO2-/NO3- and the nitrosyl group of N-nitrosomorpholine were derived exclusively from one or both of the terminal guanido nitrogens of arginine. Chromatographic analysis showed that the other product of the L-arginine synthesis of NO2-/NO3- was L-citrulline. The role of the respiratory burst in NO2-/NO3- synthesis was examined using the macrophage cell lines J774.16 and J774 C3C. Both cell lines synthesized similar amounts of NO2-/NO3-. However, J774 C3C cells do not produce superoxide and hence do not exhibit the respiratory burst. Additional experiments also ruled out the involvement of the respiratory burst in NO2-/NO3- synthesis. | lld:pubmed |
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| pubmed-article:2819872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2819872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2819872 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2819872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2819872 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2819872 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2819872 | pubmed:author | pubmed-author:IyengarRR | lld:pubmed |
| pubmed-article:2819872 | pubmed:author | pubmed-author:MarlettaM AMA | lld:pubmed |
| pubmed-article:2819872 | pubmed:author | pubmed-author:StuehrD JDJ | lld:pubmed |
| pubmed-article:2819872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2819872 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:2819872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2819872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2819872 | pubmed:pagination | 6369-73 | lld:pubmed |
| pubmed-article:2819872 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2819872 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2819872 | pubmed:articleTitle | Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. | lld:pubmed |
| pubmed-article:2819872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2819872 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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