| pubmed-article:2809274 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C1704628 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0025241 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:2809274 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:2809274 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2809274 | pubmed:dateCreated | 1989-11-30 | lld:pubmed |
| pubmed-article:2809274 | pubmed:abstractText | The effects of heat and the interaction between hyperthermia and alkylating agents, such as cisplatin (CDDP) and melphalan (L-PAM) in human malignant melanoma biopsies have been investigated by a short-term assay based upon the inhibition of 3H-thymidine incorporation. Cell suspensions from 50 cutaneous and lymph nodal metastases were heated at 40.5 degrees C or at 42 degrees C for 1 h. There were significant antiproliferative effects due to heat in 10% of the tumors exposed to 40.5 degrees C and 34% to 42 degrees C. Thermal resistance was evident in 73% (at 40.5 degrees C) and 54% (at 43 degrees C) of tumors, and there was significant enhancement of cell growth in 17% and 12% of tumors. The combined effects of hyperthermia and drugs were studied on 36 tumors. Cell suspensions were exposed to different concentrations of CDDP or L-PAM for 1 h at 40.5 degrees C and 42 degrees C. Synergy between heat and CDDP was observed in 7% of cases treated with the lowest drug dose and 38% of cases treated with the highest (40.5 degrees C), with only a slight increase in the frequency of synergy at 42 degrees C. Synergy between heat and L-PAM was also observed in 12% to 44% of tumors at 42 degrees C as a function of drug concentration. | lld:pubmed |
| pubmed-article:2809274 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2809274 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2809274 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2809274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2809274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2809274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2809274 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2809274 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2809274 | pubmed:issn | 0737-1454 | lld:pubmed |
| pubmed-article:2809274 | pubmed:author | pubmed-author:VillaRR | lld:pubmed |
| pubmed-article:2809274 | pubmed:author | pubmed-author:VagliniMM | lld:pubmed |
| pubmed-article:2809274 | pubmed:author | pubmed-author:SilvestriniRR | lld:pubmed |
| pubmed-article:2809274 | pubmed:author | pubmed-author:DaidoneM GMG | lld:pubmed |
| pubmed-article:2809274 | pubmed:author | pubmed-author:ZaffaroniNN | lld:pubmed |
| pubmed-article:2809274 | pubmed:author | pubmed-author:SantinamiMM | lld:pubmed |
| pubmed-article:2809274 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2809274 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:2809274 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2809274 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2809274 | pubmed:pagination | 385-94 | lld:pubmed |
| pubmed-article:2809274 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:meshHeading | pubmed-meshheading:2809274-... | lld:pubmed |
| pubmed-article:2809274 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2809274 | pubmed:articleTitle | Antitumor activity of hyperthermia alone or in combination with cisplatin and melphalan in primary cultures of human malignant melanoma. | lld:pubmed |
| pubmed-article:2809274 | pubmed:affiliation | Divisione di Oncologia Sperimentale C, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy. | lld:pubmed |
| pubmed-article:2809274 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2809274 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2809274 | lld:pubmed |
