| pubmed-article:280711 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:280711 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:280711 | lifeskim:mentions | umls-concept:C0301896 | lld:lifeskim |
| pubmed-article:280711 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:280711 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:280711 | lifeskim:mentions | umls-concept:C0729502 | lld:lifeskim |
| pubmed-article:280711 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:280711 | pubmed:dateCreated | 1979-1-24 | lld:pubmed |
| pubmed-article:280711 | pubmed:abstractText | Spleen natural killer (NK) activity was investigated in cells from C57BL/6J mice treated with various chemotherapeutic agents; 51Cr-labeled YAC-1 lymphoma cells were used as targets. Treatment with azathioprine (a single injection of 100-400 mg/kg ip or 5 daily doses of 80 mg/kg lp) and cyclophosphamide (a single injection of 50--200 mg/kg ip or 5 daily doses of 25 mg/kg ip) resulted in a marked dose-dependent inhibition of NK activity 2 days later. NK cells recovered rapidly from drug-induced suppression; by 7 days after drug treatment, no difference from control values was observed. Dimethyltriazenoimidazole carboxamide (20--200 mg/kg ip) and adriamycin (10--15 mg/kg iv) did not impair natural cytotoxicity per unit number of lymphoid cells, daunomycin (10 mg/kg iv) caused borderline impairment of NK acitivity, and N-trifluoroacetyl-adriamycin-14-valerate (80 mg/kg iv) markedly suppressed natural cytotoxicity. These results are discussed in light of the known effects of these agents on T-cells, B-cells, and K-cells and on hematopoietic histocompatibility-type reactions. | lld:pubmed |
| pubmed-article:280711 | pubmed:language | eng | lld:pubmed |
| pubmed-article:280711 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:280711 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:280711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:280711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:280711 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:280711 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:280711 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:280711 | pubmed:author | pubmed-author:VecchiAA | lld:pubmed |
| pubmed-article:280711 | pubmed:author | pubmed-author:MantovaniAA | lld:pubmed |
| pubmed-article:280711 | pubmed:author | pubmed-author:SpreaficoFF | lld:pubmed |
| pubmed-article:280711 | pubmed:author | pubmed-author:PeriGG | lld:pubmed |
| pubmed-article:280711 | pubmed:author | pubmed-author:LuiniWW | lld:pubmed |
| pubmed-article:280711 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:280711 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:280711 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:280711 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:280711 | pubmed:pagination | 1255-61 | lld:pubmed |
| pubmed-article:280711 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:280711 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:280711 | pubmed:articleTitle | Effect of chemotherapeutic agents on natural cell-mediated cytotoxicity in mice. | lld:pubmed |
| pubmed-article:280711 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:280711 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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