| pubmed-article:2799390 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2799390 | lifeskim:mentions | umls-concept:C0085669 | lld:lifeskim |
| pubmed-article:2799390 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2799390 | lifeskim:mentions | umls-concept:C1422634 | lld:lifeskim |
| pubmed-article:2799390 | lifeskim:mentions | umls-concept:C0597716 | lld:lifeskim |
| pubmed-article:2799390 | pubmed:issue | 4928 | lld:pubmed |
| pubmed-article:2799390 | pubmed:dateCreated | 1989-11-13 | lld:pubmed |
| pubmed-article:2799390 | pubmed:abstractText | The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to chromosome region 19p13.2-p13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias. The majority of t(1;19)(q23;p13)-carrying leukemias and cell lines studied contained rearrangements of E2A as determined by DNA blot analyses. The rearrangements altered the E2A transcriptional unit, resulting in the synthesis of a transcript larger than the normal-sized E2A mRNAs in one of the cell lines with this translocation. These observations indicate that the gene for a transcription factor is located at the breakpoint of a consistently recurring chromosomal translocation in many acute leukemias and suggest a direct role for alteration of such factors in the pathogenesis of some malignancies. | lld:pubmed |
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| pubmed-article:2799390 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2799390 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2799390 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2799390 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2799390 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2799390 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2799390 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:BaltimoreDD | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:ClearyM LML | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:SmithS DSD | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:CarrollA JAJ | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:DonlonT ATA | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:McDonaldM EME | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:McGeeD MDM | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:MurreCC | lld:pubmed |
| pubmed-article:2799390 | pubmed:author | pubmed-author:MellentinJ... | lld:pubmed |
| pubmed-article:2799390 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2799390 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:2799390 | pubmed:volume | 246 | lld:pubmed |
| pubmed-article:2799390 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2799390 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2799390 | pubmed:pagination | 379-82 | lld:pubmed |
| pubmed-article:2799390 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2799390 | pubmed:meshHeading | pubmed-meshheading:2799390-... | lld:pubmed |
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| pubmed-article:2799390 | pubmed:meshHeading | pubmed-meshheading:2799390-... | lld:pubmed |
| pubmed-article:2799390 | pubmed:meshHeading | pubmed-meshheading:2799390-... | lld:pubmed |
| pubmed-article:2799390 | pubmed:meshHeading | pubmed-meshheading:2799390-... | lld:pubmed |
| pubmed-article:2799390 | pubmed:meshHeading | pubmed-meshheading:2799390-... | lld:pubmed |
| pubmed-article:2799390 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2799390 | pubmed:articleTitle | The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias. | lld:pubmed |
| pubmed-article:2799390 | pubmed:affiliation | Department of Pathology, Stanford University School of Medicine, CA 94025. | lld:pubmed |
| pubmed-article:2799390 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2799390 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2799390 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6929 | entrezgene:pubmed | pubmed-article:2799390 | lld:entrezgene |
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