Linked Life Data

279011

Source:http://linkedlifedata.com/resource/pubmed/id/279011

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:279011rdf:typepubmed:Citationlld:pubmed
pubmed-article:279011lifeskim:mentionsumls-concept:C0524637lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C0009498lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C0205409lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C0009511lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1167622lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1704686lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1145667lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1704259lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1705987lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C2825311lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1879748lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1706853lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C0439751lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C2349209lld:lifeskim
pubmed-article:279011lifeskim:mentionsumls-concept:C1523987lld:lifeskim
pubmed-article:279011pubmed:issue8lld:pubmed
pubmed-article:279011pubmed:dateCreated1978-12-2lld:pubmed
pubmed-article:279011pubmed:abstractTextAn intact alternative pathway of complement activation was assembled from six isolated proteins present at their respective physiological concentrations (C3, 1200 microgram/ml: factor B, 200 microgram/ml; factor D, 2 microgram/ml; beta1H, 560 microgram/ml; C3b inactivator, 34 microgram/ml; and native properdin, 20 microgram/ml). Initiation of the pathway required the presence of five of these proteins not including properdin. The initial C3 convertase of the system was shown to be a fluid-phase rather than a surface-bound enzyme. The ability of the pathway to discriminate between activator and nonactivator was found to reside in the bound C3b molecule. When bound to the surface of an activator through its labile binding site, C3b interacts with surface structures of the activator through another site on the molecule. This interaction results in diminished beta1H binding to C3b and thereby allows the bound C3b molecule to escape control and participate in C3 convertase formation. Thus, initiation of the alternative pathway is a two-step process, the first being non-specific and the second being discriminatory.lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:languageenglld:pubmed
pubmed-article:279011pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:citationSubsetIMlld:pubmed
pubmed-article:279011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:279011pubmed:statusMEDLINElld:pubmed
pubmed-article:279011pubmed:monthAuglld:pubmed
pubmed-article:279011pubmed:issn0027-8424lld:pubmed
pubmed-article:279011pubmed:authorpubmed-author:Müller-Eberha...lld:pubmed
pubmed-article:279011pubmed:authorpubmed-author:SchreiberR...lld:pubmed
pubmed-article:279011pubmed:authorpubmed-author:LesavreP HPHlld:pubmed
pubmed-article:279011pubmed:authorpubmed-author:PangburnM KMKlld:pubmed
pubmed-article:279011pubmed:issnTypePrintlld:pubmed
pubmed-article:279011pubmed:volume75lld:pubmed
pubmed-article:279011pubmed:ownerNLMlld:pubmed
pubmed-article:279011pubmed:authorsCompleteYlld:pubmed
pubmed-article:279011pubmed:pagination3948-52lld:pubmed
pubmed-article:279011pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-H...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-P...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-B...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-C...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-C...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-C...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-C...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-C...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-C...lld:pubmed
pubmed-article:279011pubmed:meshHeadingpubmed-meshheading:279011-C...lld:pubmed
pubmed-article:279011pubmed:year1978lld:pubmed
pubmed-article:279011pubmed:articleTitleInitiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins.lld:pubmed
pubmed-article:279011pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:279011pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
entrez-gene:718entrezgene:pubmedpubmed-article:279011lld:entrezgene
entrez-gene:629entrezgene:pubmedpubmed-article:279011lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:279011lld:pubmed
More...