| pubmed-article:2789474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2789474 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:2789474 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2789474 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2789474 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:2789474 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:2789474 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2789474 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2789474 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2789474 | pubmed:dateCreated | 1989-10-26 | lld:pubmed |
| pubmed-article:2789474 | pubmed:abstractText | This study was undertaken to explain the molecular basis for the diverse pathology and clinical behavior of postthymic T cell malignancies. Total cellular RNAs were extracted from four HTLV-1 positive and ten HTLV-1-negative T cell lymphomas and cell lines, and investigated for homology with cloned DNA probes specific for interleukin-2 (IL-2), IL-2 receptor (IL-2R), transforming growth factor beta (TGF-beta), platelet-derived growth factor (PDGF), and epidermal growth factor receptor (EGF-R). Tumor cells associated with clinically high grade HTLV-1-positive adult T cell leukemia (ATL) and large cell morphology (T immunoblastic lymphomas) were found to have higher levels of expression of IL-2 and TGF-beta genes than low grade T cell neoplasms (mycosis fungoides and Sezary's syndrome). High expression of IL-2R gene was restricted to Ki-1-positive lymphomas and to one ATL. Cell lines corresponding to the advanced stage of a cutaneous T cell lymphoma (CTCL) showed enhanced expression of PDGF. Therefore, high grade T cell malignancies had consistently elevated expression of growth factor/receptor (GF/R) genes. Expression of EGF-R was negligible in all T cell malignancies. An inverse relationship was found between the expression of T cell antigen receptor (differentiation antigen) and GF/R (activation antigen) genes, accounting for the frequent aberrant expression of T cell antigens in high grade T cell lymphomas. The results suggest that post-thymic T cell malignancies derived from activated T cells produce and secrete GF, conferring a growth advantage on neoplastic T cells, and correlating well with their histologic subtype and clinical behavior. | lld:pubmed |
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| pubmed-article:2789474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2789474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2789474 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2789474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2789474 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2789474 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:2789474 | pubmed:author | pubmed-author:KadinM EME | lld:pubmed |
| pubmed-article:2789474 | pubmed:author | pubmed-author:SuI JIJ | lld:pubmed |
| pubmed-article:2789474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2789474 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:2789474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2789474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2789474 | pubmed:pagination | 439-45 | lld:pubmed |
| pubmed-article:2789474 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2789474 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2789474 | pubmed:articleTitle | Expression of growth factor/receptor genes in postthymic T cell malignancies. | lld:pubmed |
| pubmed-article:2789474 | pubmed:affiliation | Department of Pathology, National Taiwan University Hospital, Taipei, Republic of China. | lld:pubmed |
| pubmed-article:2789474 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2789474 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2789474 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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