| pubmed-article:2788034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2788034 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2788034 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2788034 | lifeskim:mentions | umls-concept:C0082758 | lld:lifeskim |
| pubmed-article:2788034 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:2788034 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:2788034 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2788034 | pubmed:dateCreated | 1989-9-8 | lld:pubmed |
| pubmed-article:2788034 | pubmed:abstractText | Interleukin-6 mediates pleiotropic functions in various types of cells through its specific receptor (IL-6-R), the cDNA of which has already been cloned. We report here that an 80 kd single polypeptide chain (IL-6-R) is involved in IL-6 binding and that IL-6 triggers the association of this receptor with a non-ligand-binding membrane glycoprotein, gp130. The association takes place at 37 degrees C within 5 min and is stable for at least 40 min in the presence of IL-6, but does not occur at 0 degree C. Human IL-6-R can associate with a murine gp130 homolog and is functional in murine cells. Mutant IL-6-R lacking the intracytoplasmic portion is functional, suggesting that the two polypeptide chains interact to involve their extracellular portion. In fact, a soluble IL-6-R lacking the transmembrane and intracytoplasmic domains can associate with gp130 in the presence of IL-6 and mediate its function. These findings indicate that the complex of IL-6 and IL-6-R can interact with a non-ligand-binding membrane glycoprotein, gp130, extracellularly and can provide the IL-6 signal. | lld:pubmed |
| pubmed-article:2788034 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2788034 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2788034 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2788034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2788034 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2788034 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:YamasakiKK | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:HirataYY | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:MatsudaTT | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:HiranoTT | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:KishimotoTT | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:YasukawaKK | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:TagaTT | lld:pubmed |
| pubmed-article:2788034 | pubmed:author | pubmed-author:HibiMM | lld:pubmed |
| pubmed-article:2788034 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2788034 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:2788034 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:2788034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2788034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2788034 | pubmed:pagination | 573-81 | lld:pubmed |
| pubmed-article:2788034 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2788034 | pubmed:meshHeading | pubmed-meshheading:2788034-... | lld:pubmed |
| pubmed-article:2788034 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2788034 | pubmed:articleTitle | Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. | lld:pubmed |
| pubmed-article:2788034 | pubmed:affiliation | Division of Immunology, Osaka University, Japan. | lld:pubmed |
| pubmed-article:2788034 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2788034 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2788034 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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