| pubmed-article:2787830 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2787830 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:2787830 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2787830 | lifeskim:mentions | umls-concept:C0038402 | lld:lifeskim |
| pubmed-article:2787830 | lifeskim:mentions | umls-concept:C0018850 | lld:lifeskim |
| pubmed-article:2787830 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:2787830 | lifeskim:mentions | umls-concept:C1550147 | lld:lifeskim |
| pubmed-article:2787830 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2787830 | pubmed:dateCreated | 1989-9-5 | lld:pubmed |
| pubmed-article:2787830 | pubmed:abstractText | We report that streptococcal cell wall (SCW)-induced arthritis in rats, a T cell-dependent chronic, erosive polyarthritis, can be prevented by pretreatment of the rats with the mycobacterial 65-kD heat shock protein. This 65-kD protein shows extensive amino acid homology with prokaryotic and eukaryotic 65-kD heat shock proteins and is a ubiquitous bacterial common antigen. Both the clinical and histopathologic manifestations of the arthritis were prevented completely when rats were pretreated with 50 micrograms of 65-kD protein intraperitoneally at 35, 25, 15, or 5 d before administration of SCW. In such protected rats, SCW-specific T cell responses were suppressed, as compared with responses in arthritic rats. Pretreatment with 65-kD protein had no effect on the production of antibodies against SCW, on a nonspecific inflammatory reaction (zymosan-induced arthritis), or on general cellular immunity in vivo (delayed type hypersensitivity reaction to a nonrelated protein antigen). Furthermore, the protection against SCW arthritis was transferable by splenic T cells to naive recipients. Our data show that pretreatment with the 65-kD mycobacterial heat shock protein protects rats against a subsequent bacterium-induced arthritis. This protection is immunologically specific and resides in the lymphoid cell population. | lld:pubmed |
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| pubmed-article:2787830 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2787830 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2787830 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2787830 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2787830 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2787830 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2787830 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2787830 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:2787830 | pubmed:author | pubmed-author:van der ZeeRR | lld:pubmed |
| pubmed-article:2787830 | pubmed:author | pubmed-author:Van EdenWW | lld:pubmed |
| pubmed-article:2787830 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:2787830 | pubmed:author | pubmed-author:HogervorstE... | lld:pubmed |
| pubmed-article:2787830 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:2787830 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2787830 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2787830 | pubmed:volume | 170 | lld:pubmed |
| pubmed-article:2787830 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2787830 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2787830 | pubmed:pagination | 449-66 | lld:pubmed |
| pubmed-article:2787830 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2787830 | pubmed:meshHeading | pubmed-meshheading:2787830-... | lld:pubmed |
| pubmed-article:2787830 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2787830 | pubmed:articleTitle | Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein. | lld:pubmed |
| pubmed-article:2787830 | pubmed:affiliation | Department of Rheumatology, University Hospital Nijmegen, The Netherlands. | lld:pubmed |
| pubmed-article:2787830 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2787830 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
