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| pubmed-article:2786910 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2786910 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:2786910 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:2786910 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2786910 | pubmed:dateCreated | 1989-7-31 | lld:pubmed |
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| pubmed-article:2786910 | pubmed:abstractText | In order to investigate the genetic basis for natural anti-DNA immune responses, we isolated and sequenced the variable gene elements (VH and VL) encoding an anti-DNA antibody expressed by a human hybridoma of normal origin (Kim4.6) and compared these sequences with those reported for four other human anti-DNA antibodies. The Kim4.6 antibody leader and VH segments were identical in nucleotide sequence with the VH1.9III germ-line VH3 gene, and the Kim4.6VL segment showed 98% nucleotide sequence identity with a V lambda I subgroup gene expressed in a Burkitt's lymphoma. Comparative analysis of Kim4.6 and other human hybridoma anti-DNA antibodies indicated that anti-DNA immune responses are diverse in terms of VH and VL gene utilization but may exhibit a bias toward rearrangement of VH genes that are over-represented in the fetal pre-B cell repertoire. Moreover, Kim4.6 and three of four other sequenced human anti-DNA antibodies appear to use a germ-line diversity gene, DXP'1, which may represent a counterpart of the DFL16.1 segment utilized in murine responses to the hapten nitrophenyl. Taken together, our findings indicate that anti-DNA immune responses can be encoded by nonmutated VH genes and that the elements and molecular mechanisms which engender this response are essentially the same among natural and lupus-associated anti-DNA antibodies. Our data also suggest that natural autoimmune responses originate early in B cell ontogeny as is consistent with the hypothesis that autoreactivity plays a major role in shaping the normal immune repertoire. | lld:pubmed |
| pubmed-article:2786910 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2786910 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2786910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2786910 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2786910 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2786910 | pubmed:author | pubmed-author:OokT HTH | lld:pubmed |
| pubmed-article:2786910 | pubmed:author | pubmed-author:KwongP CPC | lld:pubmed |
| pubmed-article:2786910 | pubmed:author | pubmed-author:CairnsEE | lld:pubmed |
| pubmed-article:2786910 | pubmed:author | pubmed-author:COLTO COC | lld:pubmed |
| pubmed-article:2786910 | pubmed:author | pubmed-author:SiminovitchK... | lld:pubmed |
| pubmed-article:2786910 | pubmed:author | pubmed-author:MisenerVV | lld:pubmed |
| pubmed-article:2786910 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2786910 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2786910 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:2786910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2786910 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2786910 | pubmed:pagination | 685-91 | lld:pubmed |
| pubmed-article:2786910 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2786910 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2786910 | pubmed:articleTitle | Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. Implications for the molecular basis of human autoimmune responses. | lld:pubmed |
| pubmed-article:2786910 | pubmed:affiliation | Department of Medicine, University of Toronto, Ontario. | lld:pubmed |
| pubmed-article:2786910 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2786910 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2786910 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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