| pubmed-article:2784568 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C0003315 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:2784568 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2784568 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2784568 | pubmed:dateCreated | 1989-5-5 | lld:pubmed |
| pubmed-article:2784568 | pubmed:abstractText | A T-cell clone, 10BK.1, was established from the draining lymph nodes of (B10 x B10.BR)F1 mice immunized with ovalbumin (OVA) according to standard protocols. Upon coculture with the antigen, 10BK.1 cells reacted by production of lymphokines and by proliferation despite the absence of additional antigen-presenting cells. These T cells do not express major histocompatibility complex (MHC) class II molecules on the cell surface as assessed on the basis of several criteria: by cytofluorometric analysis I-A and I-E determinants were not detectable; 10BK.1 cells could not act as antigen-presenting cells for long-term-cultured MHC class II-restricted T-cell clones; and monoclonal antibodies directed at both MHC class II isotypic complexes (I-A, I-E) did not suppress their OVA-induced activation. In contrast, proliferation of 10BK.1 T cells in response to OVA was abrogated by antibodies directed at H-2Kb antigens. Inhibition experiments employing antibodies directed at Lyt-2 and L3T4 antigens in addition to cytofluorometric analysis revealed that T-cell clone 10BK.1 exhibits the Thy-1+,Lyt-2+,Ly-1-,L3T4- phenotype. 10BK.1 cells pulsed with OVA and fixed with glutaraldehyde induced proliferation of untreated 10BK.1 cells. These data support the theory that 10BK.1 T cells present the exogenous globular protein OVA to one another in an MHC class I-restricted manner, resulting in cell activation and proliferation independent of added accessory cells. | lld:pubmed |
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| pubmed-article:2784568 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2784568 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2784568 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2784568 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2784568 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2784568 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2784568 | pubmed:author | pubmed-author:DickTT | lld:pubmed |
| pubmed-article:2784568 | pubmed:author | pubmed-author:Reske-KunzA... | lld:pubmed |
| pubmed-article:2784568 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2784568 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2784568 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2784568 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2784568 | pubmed:pagination | 2316-20 | lld:pubmed |
| pubmed-article:2784568 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2784568 | pubmed:meshHeading | pubmed-meshheading:2784568-... | lld:pubmed |
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| pubmed-article:2784568 | pubmed:meshHeading | pubmed-meshheading:2784568-... | lld:pubmed |
| pubmed-article:2784568 | pubmed:meshHeading | pubmed-meshheading:2784568-... | lld:pubmed |
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| pubmed-article:2784568 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2784568 | pubmed:articleTitle | Major histocompatibility complex class I-restricted activation of cloned T cells by a soluble protein in the absence of accessory cells. | lld:pubmed |
| pubmed-article:2784568 | pubmed:affiliation | Institut für Immunologie, Johannes Gutenberg-Universität, Mainz, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:2784568 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2784568 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2784568 | lld:pubmed |
