| pubmed-article:2783331 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2783331 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2783331 | lifeskim:mentions | umls-concept:C1513380 | lld:lifeskim |
| pubmed-article:2783331 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2783331 | pubmed:dateCreated | 1989-2-9 | lld:pubmed |
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| pubmed-article:2783331 | pubmed:abstractText | We have studied the genetic diversity of the TCR repertoire to the murine alloantigen I-Abm12 by generating a panel of 178 C57BL/10-derived I-Abm12-reactive T cell hybridomas. The expression of V alpha and V beta gene families was examined in this panel and the frequency of expression of V beta, but not ofV alpha, gene families differed significantly from that observed in a companion panel of random C57BL/10-derived hybridomas. The V beta 5 gene family was expressed significantly less frequently while the V beta 14, V beta 15, and V beta 16 genes were expressed significantly more frequently in the panel of I-Abm12-reactive than in the panel of random hybridomas. The junctional regions (VJ alpha and VDJ beta) of TCR V alpha and V beta genes from selected I-Abm12-specific hybridomas were amplified using the polymerase chain reaction, and directly sequenced. Surprisingly, no conserved J alpha, D beta, J beta, or N region-encoded sequences among these selected I-Abm12-reactive TCRs were identified. Thus, the T cell response to an I-A alloantigen that differs by only three amino acid residues from the I-A molecule of the responding strain is genetically complex but nonrandom. We have estimated that the repertoire to this alloantigen is comprised of at least 37 different TCRs. | lld:pubmed |
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| pubmed-article:2783331 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2783331 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2783331 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2783331 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2783331 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2783331 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2783331 | pubmed:author | pubmed-author:HornGG | lld:pubmed |
| pubmed-article:2783331 | pubmed:author | pubmed-author:WhiteJJ | lld:pubmed |
| pubmed-article:2783331 | pubmed:author | pubmed-author:PalmerEE | lld:pubmed |
| pubmed-article:2783331 | pubmed:author | pubmed-author:ErlichH AHA | lld:pubmed |
| pubmed-article:2783331 | pubmed:author | pubmed-author:Bie?KK | lld:pubmed |
| pubmed-article:2783331 | pubmed:author | pubmed-author:YagüeJJ | lld:pubmed |
| pubmed-article:2783331 | pubmed:author | pubmed-author:AppelV BVB | lld:pubmed |
| pubmed-article:2783331 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2783331 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2783331 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:2783331 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2783331 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2783331 | pubmed:pagination | 115-33 | lld:pubmed |
| pubmed-article:2783331 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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