| pubmed-article:2779555 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2779555 | lifeskim:mentions | umls-concept:C0038975 | lld:lifeskim |
| pubmed-article:2779555 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2779555 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:2779555 | lifeskim:mentions | umls-concept:C0039476 | lld:lifeskim |
| pubmed-article:2779555 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2779555 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:2779555 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:2779555 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2779555 | pubmed:dateCreated | 1989-10-13 | lld:pubmed |
| pubmed-article:2779555 | pubmed:abstractText | Simian virus 40 (SV40)-mediated transformation of human fibroblasts offers an experimental system for studying both carcinogenesis and cellular aging, since such transformants show the typical features of altered cellular growth but still have a limited life span in culture and undergo senescence. We have previously demonstrated (D. S. Neufeld, S. Ripley, A. Henderson, and H. L. Ozer, Mol. Cell. Biol. 7:2794-2802, 1987) that transformants generated with origin-defective mutants of SV40 show an increased frequency of overcoming senescence and becoming immortal. To clarify further the role of large T antigen, we have generated immortalized transformants by using origin-defective mutants of SV40 encoding a heat-labile large T antigen (tsA58 transformants). At a temperature permissive for large-T-antigen function (35 degrees C), the cell line AR5 had properties resembling those of cell lines transformed with wild-type SV40. However, the AR5 cells were unable to proliferate or form colonies at temperatures restrictive for large-T-antigen function (39 degrees C), demonstrating a continuous need for large T antigen even in immortalized human fibroblasts. Such immortal temperature-dependent transformants should be useful cell lines for the identification of other cellular or viral gene products that induce cell proliferation in human cells. | lld:pubmed |
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| pubmed-article:2779555 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2779555 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2779555 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2779555 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2779555 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2779555 | pubmed:author | pubmed-author:TraganosFF | lld:pubmed |
| pubmed-article:2779555 | pubmed:author | pubmed-author:OzerH LHL | lld:pubmed |
| pubmed-article:2779555 | pubmed:author | pubmed-author:GOHK OKO | lld:pubmed |
| pubmed-article:2779555 | pubmed:author | pubmed-author:DARR NRN | lld:pubmed |
| pubmed-article:2779555 | pubmed:author | pubmed-author:KaplanPP | lld:pubmed |
| pubmed-article:2779555 | pubmed:author | pubmed-author:RadnaR LRL | lld:pubmed |
| pubmed-article:2779555 | pubmed:author | pubmed-author:CatonYY | lld:pubmed |
| pubmed-article:2779555 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2779555 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2779555 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2779555 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2779555 | pubmed:pagination | 3093-6 | lld:pubmed |
| pubmed-article:2779555 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2779555 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2779555 | pubmed:articleTitle | Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent. | lld:pubmed |
| pubmed-article:2779555 | pubmed:affiliation | Department of Biological Science, Hunter College, City University of New York, New York 10021. | lld:pubmed |
| pubmed-article:2779555 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2779555 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2779555 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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