| pubmed-article:2770765 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2770765 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:2770765 | lifeskim:mentions | umls-concept:C0032403 | lld:lifeskim |
| pubmed-article:2770765 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:2770765 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:2770765 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:2770765 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2770765 | pubmed:dateCreated | 1989-10-10 | lld:pubmed |
| pubmed-article:2770765 | pubmed:abstractText | DNA damage inflicted by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine, or by UV254nm, stimulated the catabolism of protein-bound poly(ADP-ribose) in the chromatin of cultured hepatocytes. The stimulation was highest at the largest doses of DNA-damaging treatment. As a consequence, the half-life of ADP-ribosyl polymers may drop to less than 41 s. This rapid turnover contrasts with the slow catabolism of a constitutive fraction of polymers exhibiting a half-life of 7.7 h. Our data suggest that post-incisional stimulation of poly(ADP-ribose) biosynthesis in DNA-excision repair is coupled with an adaptation of poly(ADP-ribose) catabolism in mammalian cells. | lld:pubmed |
| pubmed-article:2770765 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2770765 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2770765 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2770765 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2770765 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2770765 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:2770765 | pubmed:author | pubmed-author:AlthausF RFR | lld:pubmed |
| pubmed-article:2770765 | pubmed:author | pubmed-author:Alvarez-Gonza... | lld:pubmed |
| pubmed-article:2770765 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2770765 | pubmed:volume | 218 | lld:pubmed |
| pubmed-article:2770765 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2770765 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2770765 | pubmed:pagination | 67-74 | lld:pubmed |
| pubmed-article:2770765 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2770765 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2770765 | pubmed:articleTitle | Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents. | lld:pubmed |
| pubmed-article:2770765 | pubmed:affiliation | University of Zürich-Tierspital, Institute of Pharmacology and Biochemistry, Switzerland. | lld:pubmed |
| pubmed-article:2770765 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2770765 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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