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pubmed-article:2765638pubmed:abstractTextTwo-phase medical surveys, in which a large sample is assessed with an inexpensive screening instrument and a subsample is selected for a more thorough diagnostic evaluation, appear to have great merit in the epidemiologic study of certain rare disorders. We present the optimal design of two-phase surveys when resources are fixed and when 100% of those screened positive in the first phase must be included in the second-phase evaluation. We go on to examine the relative efficiency of this two-phase design compared to a single-phase design in which all resources are used in a survey that employs the diagnostic evaluation. Given information on the accuracy of the screen and the prevalence of the disorder, the utility of the two-phase design depends on the relative cost of the screening to the diagnostic assessments.lld:pubmed
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pubmed-article:2765638pubmed:issn0006-341Xlld:pubmed
pubmed-article:2765638pubmed:authorpubmed-author:ShroutP EPElld:pubmed
pubmed-article:2765638pubmed:authorpubmed-author:NewmanS CSClld:pubmed
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pubmed-article:2765638pubmed:volume45lld:pubmed
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pubmed-article:2765638pubmed:pagination549-55lld:pubmed
pubmed-article:2765638pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:2765638pubmed:year1989lld:pubmed
pubmed-article:2765638pubmed:articleTitleDesign of two-phase prevalence surveys of rare disorders.lld:pubmed
pubmed-article:2765638pubmed:affiliationDivision of Biostatistics, Columbia University School of Public Health, New York, New York 10032.lld:pubmed
pubmed-article:2765638pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2765638pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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