| pubmed-article:2764521 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2764521 | lifeskim:mentions | umls-concept:C0009402 | lld:lifeskim |
| pubmed-article:2764521 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2764521 | lifeskim:mentions | umls-concept:C0007994 | lld:lifeskim |
| pubmed-article:2764521 | lifeskim:mentions | umls-concept:C0035973 | lld:lifeskim |
| pubmed-article:2764521 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:2764521 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2764521 | pubmed:dateCreated | 1989-9-11 | lld:pubmed |
| pubmed-article:2764521 | pubmed:abstractText | SD rats bearing acetoxymethylmethylnitrosamine-induced colorectal carcinomas were treated by i.v. administration of trans-imidazolium-bisimidazoletetrachlororuthenate (III) ImH(RuIm2Cl4), bisbenzimidazolium-benzimidazolepentachlororuthenate (III) (BzImH)2(RuBzImCl5) and trans-indazolium-bisindazoletetrachlororuthenate (III) In-dH(ruInd2Cl4). The dose levels used were 0.022 mmol/kg body weight administered twice weekly over ten weeks for all compounds and, additionally, 0.015 mmol/kg for ImH(RuIm2Cl4). All compounds caused a tumor growth inhibition exceeding 90%; differences were found with regard to toxicity: ImH(RuIm2Cl4 and (BzImH)2(RuBzImCl5) caused dose-related decreases in body weight and increases in mortality as shown by 21% and 29% body weight loss compared to controls as well as 10% and 45% mortality for the two dosages of the first compound, and 9% body weight loss compared to controls as well as 7% mortality for the latter compound. In contrast, equimolar administration of IndH(RuInd2Cl4) was not related to any symptoms of toxicity as evidenced by 2% body weight gain compared to controls as well as 0% mortality. Since this latter drug obviously showed remarkable activity in a highly resistant type of tumor at negligible toxicity, it certainly deserves special attention. | lld:pubmed |
| pubmed-article:2764521 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2764521 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764521 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2764521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764521 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2764521 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2764521 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:2764521 | pubmed:author | pubmed-author:SchmählDD | lld:pubmed |
| pubmed-article:2764521 | pubmed:author | pubmed-author:BergerM RMR | lld:pubmed |
| pubmed-article:2764521 | pubmed:author | pubmed-author:KepplerB KBK | lld:pubmed |
| pubmed-article:2764521 | pubmed:author | pubmed-author:GarzonF TFT | lld:pubmed |
| pubmed-article:2764521 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2764521 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2764521 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2764521 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2764521 | pubmed:pagination | 761-5 | lld:pubmed |
| pubmed-article:2764521 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:meshHeading | pubmed-meshheading:2764521-... | lld:pubmed |
| pubmed-article:2764521 | pubmed:articleTitle | Efficacy of new ruthenium complexes against chemically induced autochthonous colorectal carcinoma in rats. | lld:pubmed |
| pubmed-article:2764521 | pubmed:affiliation | Institute of Toxicology and Chemotherapy, German Cancer Research Center, F.R.G. | lld:pubmed |
| pubmed-article:2764521 | pubmed:publicationType | Journal Article | lld:pubmed |
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