| pubmed-article:2758320 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C2699239 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C1527311 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C0044222 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:2758320 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:2758320 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2758320 | pubmed:dateCreated | 1989-9-8 | lld:pubmed |
| pubmed-article:2758320 | pubmed:abstractText | The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatment with H-7 reduced the extent of brain edema formation in a dose-dependent manner. The fact that H-7 treatment prevented the accumulation of water and certain electrolytes in the brain indicates that the protein kinase C may be activated not only in the neuronal structures but also in the microvessels during ischemia, which can lead directly or via certain calcium-mediated mechanisms to the opening of tight junctions resulting in the development of brain edema. | lld:pubmed |
| pubmed-article:2758320 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2758320 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2758320 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2758320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2758320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2758320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2758320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2758320 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2758320 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2758320 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2758320 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2758320 | pubmed:author | pubmed-author:KUNLL | lld:pubmed |
| pubmed-article:2758320 | pubmed:author | pubmed-author:KoltaiMM | lld:pubmed |
| pubmed-article:2758320 | pubmed:author | pubmed-author:OláhZZ | lld:pubmed |
| pubmed-article:2758320 | pubmed:author | pubmed-author:TósakiAA | lld:pubmed |
| pubmed-article:2758320 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2758320 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:2758320 | pubmed:volume | 490 | lld:pubmed |
| pubmed-article:2758320 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2758320 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2758320 | pubmed:pagination | 141-3 | lld:pubmed |
| pubmed-article:2758320 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:meshHeading | pubmed-meshheading:2758320-... | lld:pubmed |
| pubmed-article:2758320 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2758320 | pubmed:articleTitle | Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley CFY rats. | lld:pubmed |
| pubmed-article:2758320 | pubmed:affiliation | Laboratory of Molecular Neurobiology, Institute of Biophysics Biological Research Center, Szeged, Hungary. | lld:pubmed |
| pubmed-article:2758320 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2758320 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
