| pubmed-article:2756715 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C0037643 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C1149826 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:2756715 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:2756715 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2756715 | pubmed:dateCreated | 1989-9-7 | lld:pubmed |
| pubmed-article:2756715 | pubmed:abstractText | 1. Hydrolysis of the drug esters procaine, chloramphenicol succinate, and prednisolone succinate was studied. Addition of soman to guinea pig liver microsomes caused a dose-dependent inhibition of hydrolysis of all three substrates; at the highest soman concentration (1 microM), ester hydrolysis was totally abolished. 2. Ester hydrolysis was also measured in liver microsomes from guinea pigs pretreated with soman at a low dose (10% of LD50) or at a high dose (90% of LD50) either 1 h or 12 h before killing. Plasma-cholinesterase activity was decreased in all pretreated animals. Liver carboxylesterase activity, measured with the three drug substrates and by hydrolysis of 4-nitrophenyl acetate was increased by all pretreatments. 3. This enhancing effect varies with the substrate and increases with dose of soman. The 12 h pretreatment produced a greater increase in activity than did the 1 h pretreatment. 4. These studies indicate that soman is a potent inhibitor of carboxylesterase activity in vitro but increases the activity of the liver enzyme when administered in vivo. | lld:pubmed |
| pubmed-article:2756715 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2756715 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756715 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2756715 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2756715 | pubmed:issn | 0049-8254 | lld:pubmed |
| pubmed-article:2756715 | pubmed:author | pubmed-author:CastleM CMC | lld:pubmed |
| pubmed-article:2756715 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2756715 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:2756715 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2756715 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2756715 | pubmed:pagination | 115-21 | lld:pubmed |
| pubmed-article:2756715 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:meshHeading | pubmed-meshheading:2756715-... | lld:pubmed |
| pubmed-article:2756715 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2756715 | pubmed:articleTitle | Alteration of hepatic carboxylesterase activity by soman: inhibition in vitro and enhancement in vivo. | lld:pubmed |
| pubmed-article:2756715 | pubmed:affiliation | Department of Pharmacology, Eastern Virginia Medical School, Norfolk 23501. | lld:pubmed |
| pubmed-article:2756715 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2756715 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2756715 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
