| pubmed-article:2753925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0036974 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0678544 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0596978 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0181670 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:2753925 | lifeskim:mentions | umls-concept:C0085752 | lld:lifeskim |
| pubmed-article:2753925 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2753925 | pubmed:dateCreated | 1989-9-1 | lld:pubmed |
| pubmed-article:2753925 | pubmed:abstractText | The effect of a combined treatment with shock waves generated by a lithotripter and Adriamycin or cisplatin was examined in cells that acutely survived exposure to shock waves and proliferated afterwards. Batches of 2 x 10(6) cells were exposed to the respective drug for 50 min or for 50 min plus 72 h. During the 50-min drug exposure 500 shock waves were applied at 25 kV. The growth as a percentage of the control was determined after 72 h by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cells treated with shock waves alone showed a growth inhibition as compared to control cells. For a 50-min drug exposure with Adriamycin the dose enhancement ratio did not exceed 1.3. For a 50-min drug exposure with cisplatin at concentrations of 0.5 micrograms/ml and 5.0 micrograms/ml, growth (as a percentage of the control) after combined treatment was significantly reduced as compared to cisplatin treatment alone; the dose enhancement ratio was 3.2 at 50% growth compared to the control. This indicates that shock waves can increase the susceptibility of L1210 cells to cisplatin. For a 50-min plus 72-h drug exposure no effect of an additional treatment with shock waves, as compared to chemotherapy alone, could be observed. | lld:pubmed |
| pubmed-article:2753925 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2753925 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2753925 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2753925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2753925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2753925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2753925 | pubmed:issn | 0171-5216 | lld:pubmed |
| pubmed-article:2753925 | pubmed:author | pubmed-author:BrendelWW | lld:pubmed |
| pubmed-article:2753925 | pubmed:author | pubmed-author:DeliusMM | lld:pubmed |
| pubmed-article:2753925 | pubmed:author | pubmed-author:GambihlerSS | lld:pubmed |
| pubmed-article:2753925 | pubmed:author | pubmed-author:WilmerAA | lld:pubmed |
| pubmed-article:2753925 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2753925 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:2753925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2753925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2753925 | pubmed:pagination | 229-34 | lld:pubmed |
| pubmed-article:2753925 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:meshHeading | pubmed-meshheading:2753925-... | lld:pubmed |
| pubmed-article:2753925 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2753925 | pubmed:articleTitle | In vitro cytotoxic activity of lithotripter shock waves combined with adriamycin or with cisplatin on L1210 mouse leukemia cells. | lld:pubmed |
| pubmed-article:2753925 | pubmed:affiliation | Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:2753925 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2753925 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2753925 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2753925 | lld:pubmed |
