| pubmed-article:2752594 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2752594 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2752594 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:2752594 | lifeskim:mentions | umls-concept:C0003264 | lld:lifeskim |
| pubmed-article:2752594 | lifeskim:mentions | umls-concept:C0312639 | lld:lifeskim |
| pubmed-article:2752594 | lifeskim:mentions | umls-concept:C1407029 | lld:lifeskim |
| pubmed-article:2752594 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2752594 | pubmed:dateCreated | 1989-9-1 | lld:pubmed |
| pubmed-article:2752594 | pubmed:abstractText | The specificities of serum and intestinal antibodies from coeliac and normal individuals towards gluten-derived peptides, known to be toxic in coeliac disease, has been investigated. Though untreated coeliacs had high serum antibody levels towards gliadin and some gluten-derived peptides, antibody specificities to various toxic gluten-derived peptides were similar to normal patients. Further, no significant binding in any patient group was found to the alpha-gliadin-derived peptides B1342 (Wieser, Belitz & Ashkenazi, 1984) or the 12 amino-acid A-gliadin peptide (Kagnoff, 1985). There appears to be no direct relationship between the toxicities and the antigenic reactivity of gluten-derived peptides. Thus, the intestinal damage in coeliac disease is probably not primarily caused by antibody-dependent mechanisms. The specificities of several monoclonal antibodies which bound to wheat prolamins as well as prolamins from other coeliac-toxic cereals have also been investigated with these toxic gluten-derived peptides, in order to identify possible common epitopes. No monoclonal antibody tested bound the B1342 and 12-amino-acid A-gliadin peptide. However the monoclonal antibodies which were specific for the coeliac-toxic cereal prolamins did show the strongest binding to other coeliac-toxic gluten-derived peptides. | lld:pubmed |
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| pubmed-article:2752594 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2752594 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752594 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2752594 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2752594 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2752594 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:2752594 | pubmed:author | pubmed-author:DavidsonGG | lld:pubmed |
| pubmed-article:2752594 | pubmed:author | pubmed-author:SkerrittJ HJH | lld:pubmed |
| pubmed-article:2752594 | pubmed:author | pubmed-author:DeveryJ MJM | lld:pubmed |
| pubmed-article:2752594 | pubmed:author | pubmed-author:La BrooyJ TJT | lld:pubmed |
| pubmed-article:2752594 | pubmed:author | pubmed-author:KrillisSS | lld:pubmed |
| pubmed-article:2752594 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2752594 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:2752594 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2752594 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2752594 | pubmed:pagination | 384-90 | lld:pubmed |
| pubmed-article:2752594 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2752594 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2752594 | pubmed:articleTitle | Anti-gliadin antibody specificity for gluten-derived peptides toxic to coeliac patients. | lld:pubmed |
| pubmed-article:2752594 | pubmed:affiliation | Division of Plant Industry, North Ryde, Australia. | lld:pubmed |
| pubmed-article:2752594 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2752594 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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