| pubmed-article:2752311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2752311 | lifeskim:mentions | umls-concept:C0027819 | lld:lifeskim |
| pubmed-article:2752311 | lifeskim:mentions | umls-concept:C0027834 | lld:lifeskim |
| pubmed-article:2752311 | lifeskim:mentions | umls-concept:C0002367 | lld:lifeskim |
| pubmed-article:2752311 | lifeskim:mentions | umls-concept:C0036140 | lld:lifeskim |
| pubmed-article:2752311 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2752311 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2752311 | pubmed:dateCreated | 1989-8-31 | lld:pubmed |
| pubmed-article:2752311 | pubmed:abstractText | NB2a/dl neuroblastoma cells were exposed to aluminum chloride or aluminum lactate (0.1-1 mM) for 3 and 6 days. Additional cultures were exposed to aluminum salts as the cells were stimulated to elaborate axonal neurites by dibutyryl cyclic AMP. By phase-contrast microscopy, aluminum salts had no effect on the morphology of undifferentiated (NB2a(-] or differentiated (NB2a(+] cells, or on neuritic elaboration and maintenance. Silver straining by the Bielschowsky method, however, demonstrated argyrophilic accumulations in perikarya of many NB2a(-) and NB2a(+) cells treated with aluminum salts. At the ultrastructural level, whorls of intermediate filaments were the most prominent abnormalities in neuronal perikarya. Although phosphorylated high-molecular weight neurofilament subunits (NF-H) are normally detected by immunocytochemical analyses only within axonal neurites of NB2a/dl cells, aluminum salt treatment caused the detection of phosphorylated epitopes of NF-H within perikaryal of NB2a(-) and NB2a(+) cytoskeletons, suggesting that the argyrophilic filamentous accumulations are composed at least partly of phosphorylated NF-H. | lld:pubmed |
| pubmed-article:2752311 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2752311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2752311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2752311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2752311 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2752311 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2752311 | pubmed:author | pubmed-author:NixonR ARA | lld:pubmed |
| pubmed-article:2752311 | pubmed:author | pubmed-author:SheaT BTB | lld:pubmed |
| pubmed-article:2752311 | pubmed:author | pubmed-author:ClarkeJ FJF | lld:pubmed |
| pubmed-article:2752311 | pubmed:author | pubmed-author:PaskevichP... | lld:pubmed |
| pubmed-article:2752311 | pubmed:author | pubmed-author:WheelockT RTR | lld:pubmed |
| pubmed-article:2752311 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2752311 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:2752311 | pubmed:volume | 492 | lld:pubmed |
| pubmed-article:2752311 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2752311 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2752311 | pubmed:pagination | 53-64 | lld:pubmed |
| pubmed-article:2752311 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:meshHeading | pubmed-meshheading:2752311-... | lld:pubmed |
| pubmed-article:2752311 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2752311 | pubmed:articleTitle | Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma. | lld:pubmed |
| pubmed-article:2752311 | pubmed:affiliation | Ralph Lowell Laboratories, McLean Hospital, Belmont, MA 02178. | lld:pubmed |
| pubmed-article:2752311 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2752311 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2752311 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
