| pubmed-article:2744080 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C0021246 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:2744080 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:2744080 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2744080 | pubmed:dateCreated | 1989-8-22 | lld:pubmed |
| pubmed-article:2744080 | pubmed:abstractText | Active sensitization of guinea-pigs resulted in an increase in responsiveness and sensitivity of tracheal and lung parenchymal strips to CaCl2 (in K+-depolarised tissue), KCl, acetylcholine and histamine. Indomethacin (5 microM) preferentially enhanced the response of tracheal strips from normal animals to histamine and to a lesser extent acetylcholine but not to CaCl2 or KCl. A similar trend was observed in sensitized tissues. Indomethacin pretreatment did not cause changes in responsiveness or sensitivity of lung parenchymal strips from normal or sensitized guinea-pigs to the agonists tested. It is concluded that immunological sensitization produced a non-specific hyperresponsiveness in trachea and lung parenchymal strips. Conversely, cyclooxygenase inhibition by indomethacin elicited a selective increase in the responsiveness to certain agonists in central but not in the peripheral airways. | lld:pubmed |
| pubmed-article:2744080 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2744080 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2744080 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2744080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2744080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2744080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2744080 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2744080 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2744080 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:EspluguesJJ | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:PascualRR | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:SanzCC | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:OrtizJ LJL | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:MorcilloE JEJ | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:CortijoJJ | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:PerpiñáMM | lld:pubmed |
| pubmed-article:2744080 | pubmed:author | pubmed-author:SarríaBB | lld:pubmed |
| pubmed-article:2744080 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2744080 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:2744080 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:2744080 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2744080 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2744080 | pubmed:pagination | 467-73 | lld:pubmed |
| pubmed-article:2744080 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:meshHeading | pubmed-meshheading:2744080-... | lld:pubmed |
| pubmed-article:2744080 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2744080 | pubmed:articleTitle | Modification by indomethacin of airway contractile responses in normal and sensitized guinea-pigs. | lld:pubmed |
| pubmed-article:2744080 | pubmed:affiliation | Departamento de Farmacologia y Farmacotecnia, Universitat de València, Madrid, Spain. | lld:pubmed |
| pubmed-article:2744080 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2744080 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2744080 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2744080 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2744080 | lld:pubmed |
