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pubmed-article:2732683pubmed:abstractTextA temperature-sensitive (ts) mutant, tsG1, has been isolated from the CVS (Challenge Virus Standard) strain of rabies virus. The ts mutation affects the glycoprotein (G protein); it consists of an amino acid substitution (leucine to phenylalanine) at position 132. tsG1 exhibits a slightly reduced pathogenicity when administered via the intracerebral route and complete avirulence after intramuscular inoculation, associated with a very high protective power for adult mice. The ts mutation does not seem to block the transport of the G protein to the plasma membrane at the non-permissive temperature (39.6 degrees C). It abolishes the c.p.e. of the virus in cell cultures.lld:pubmed
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pubmed-article:2732683pubmed:articleTitleCharacterization of a new temperature-sensitive and avirulent mutant of the rabies virus.lld:pubmed
pubmed-article:2732683pubmed:affiliationLaboratoire de Génétique des Virus, CNRS, Gif sur Yvette, France.lld:pubmed
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