| pubmed-article:2732449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C1522537 | lld:lifeskim |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:2732449 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:2732449 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2732449 | pubmed:dateCreated | 1989-7-20 | lld:pubmed |
| pubmed-article:2732449 | pubmed:abstractText | In different trials, a total of 46 adults and 12 children suffering from chronic hepatitis B virus (HBV) and who were HBV-DNA- and HBeAg-positive were treated with recombinant interferon-alpha (rIFN alpha)-2A. The interferon was administered intramuscularly in different doses ranging from 1.5 MU to 20 MU/m2 of body surface, two or three times weekly during 4-6 months. Specific detection of anti-IFN antibodies by enzymoimmunoassay (EIA), radioimmunoassay (RIA) and biological assays during treatment and follow-up periods were performed. None of the children developed anti-IFN antibodies. During therapy, 12 adult patients (26%) were found to have anti-IFN antibodies. A total of five patients became HBV-DNA-negative during therapy, but in three cases a reactivation of viral replication occurred subsequently. In these three patients, the appearance of anti-IFN antibodies occurred prior to or at the same time as HBV-DNA loss. The other seven patients did not respond to therapy. In conclusion, the development of anti-IFN antibodies during rIFN alpha treatment of chronic hepatitis B may modify the response to therapy, especially if they appear before HBV-DNA negativization. | lld:pubmed |
| pubmed-article:2732449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2732449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2732449 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2732449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2732449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2732449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2732449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2732449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2732449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2732449 | pubmed:month | May | lld:pubmed |
| pubmed-article:2732449 | pubmed:issn | 0168-8278 | lld:pubmed |
| pubmed-article:2732449 | pubmed:author | pubmed-author:BartoloméJJ | lld:pubmed |
| pubmed-article:2732449 | pubmed:author | pubmed-author:CarreñoVV | lld:pubmed |
| pubmed-article:2732449 | pubmed:author | pubmed-author:PorresJ CJC | lld:pubmed |
| pubmed-article:2732449 | pubmed:author | pubmed-author:MarrónJ AJA | lld:pubmed |
| pubmed-article:2732449 | pubmed:author | pubmed-author:RuízMM | lld:pubmed |
| pubmed-article:2732449 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2732449 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:2732449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2732449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2732449 | pubmed:pagination | 351-7 | lld:pubmed |
| pubmed-article:2732449 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:2732449 | pubmed:meshHeading | pubmed-meshheading:2732449-... | lld:pubmed |
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| pubmed-article:2732449 | pubmed:meshHeading | pubmed-meshheading:2732449-... | lld:pubmed |
| pubmed-article:2732449 | pubmed:meshHeading | pubmed-meshheading:2732449-... | lld:pubmed |
| pubmed-article:2732449 | pubmed:meshHeading | pubmed-meshheading:2732449-... | lld:pubmed |
| pubmed-article:2732449 | pubmed:meshHeading | pubmed-meshheading:2732449-... | lld:pubmed |
| pubmed-article:2732449 | pubmed:meshHeading | pubmed-meshheading:2732449-... | lld:pubmed |
| pubmed-article:2732449 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2732449 | pubmed:articleTitle | Interferon antibodies in patients with chronic HBV infection treated with recombinant interferon. | lld:pubmed |
| pubmed-article:2732449 | pubmed:affiliation | Gastroenterology Department, Fundación Jiménez Díaz, Madrid, Spain. | lld:pubmed |
| pubmed-article:2732449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2732449 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2732449 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:2732449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2732449 | lld:pubmed |
