| pubmed-article:2726767 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2726767 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:2726767 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2726767 | lifeskim:mentions | umls-concept:C0812382 | lld:lifeskim |
| pubmed-article:2726767 | lifeskim:mentions | umls-concept:C1415090 | lld:lifeskim |
| pubmed-article:2726767 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:2726767 | lifeskim:mentions | umls-concept:C1414236 | lld:lifeskim |
| pubmed-article:2726767 | lifeskim:mentions | umls-concept:C1837550 | lld:lifeskim |
| pubmed-article:2726767 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2726767 | pubmed:dateCreated | 1989-7-12 | lld:pubmed |
| pubmed-article:2726767 | pubmed:abstractText | The mRNA encoding the mouse homolog of C/EBP, a rat DNA-binding protein that participates in activating a number of genes in hepatocytes, is present in liver cells at a far higher concentration than in most other cells, including spleen, kidney, muscle, and the majority of the brain. However, fat cells and intestinal cells contain 25-50% as much mRNA as liver cells. "Run-on" experiments show that the basis for the restricted cellular distribution of the mouse C/EBP mRNA is transcriptional regulation of the gene. We also show that disruption of cell-cell contacts incident to liver cell dispersion results in a prompt and extensive reduction in mouse C/EBP transcription as we had earlier shown to be the case for a group of 10 genes transcribed in a hepatocyte-specific fashion. In contrast, breaking cell contacts and plating the hepatocytes in culture leads to a prolonged increase in transcription of the Jun-B gene that encodes a widely distributed transcription factor. These results illustrate that the regulation of expression of a mammalian regulatory protein with limited tissue distribution is controlled at the level of transcription and depends on cell contacts. | lld:pubmed |
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| pubmed-article:2726767 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2726767 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2726767 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2726767 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2726767 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2726767 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2726767 | pubmed:author | pubmed-author:DarnellJ... | lld:pubmed |
| pubmed-article:2726767 | pubmed:author | pubmed-author:DeckerTT | lld:pubmed |
| pubmed-article:2726767 | pubmed:author | pubmed-author:KuoC FCF | lld:pubmed |
| pubmed-article:2726767 | pubmed:author | pubmed-author:MirkovitchJJ | lld:pubmed |
| pubmed-article:2726767 | pubmed:author | pubmed-author:XanthopoulosK... | lld:pubmed |
| pubmed-article:2726767 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2726767 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2726767 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2726767 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2726767 | pubmed:pagination | 4117-21 | lld:pubmed |
| pubmed-article:2726767 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2726767 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2726767 | pubmed:articleTitle | Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP. | lld:pubmed |
| pubmed-article:2726767 | pubmed:affiliation | Molecular Cell Biology Laboratory, Rockefeller University, New York, NY 10021. | lld:pubmed |
| pubmed-article:2726767 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2726767 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2726767 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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