| pubmed-article:2724351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2724351 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:2724351 | lifeskim:mentions | umls-concept:C1882810 | lld:lifeskim |
| pubmed-article:2724351 | lifeskim:mentions | umls-concept:C0015689 | lld:lifeskim |
| pubmed-article:2724351 | lifeskim:mentions | umls-concept:C0133860 | lld:lifeskim |
| pubmed-article:2724351 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:2724351 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2724351 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:2724351 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2724351 | pubmed:dateCreated | 1989-6-26 | lld:pubmed |
| pubmed-article:2724351 | pubmed:abstractText | We examined the effect of varying the ratio of dietary omega-3 (omega 3) to omega-6 (omega 6) on the development of pancreatic preneoplastic lesions in male Wistar rats given azaserine at 14 days of age. As the ratio of dietary omega 3 to omega 6 fatty acids increased in a diet totaling 20% by weight of fat, the development of preneoplastic atypical acinar cell nodules (AACNs) at 4 months after dosing with azaserine decreased significantly. In addition, serum levels of prostaglandin thromboxane B2, prostaglandin E2, and 6-keto-prostaglandin F1 alpha decreased significantly. The fatty acid composition of the rbc membrane was also significantly influenced by the ratio of dietary omega 3 to omega 6 fatty acids. In a second experiment, we examined the effect of dietary intervention with a different type of fat (corn oil or menhaden oil) 2 months into the 4-month postdosing period on AACN development at the end of the post-dosing period. Intervention of the omega 6 fatty acid-rich diet with the omega 3 fatty acid-rich diet significantly decreased focal development. The opposite was true when intervention involved substituting the omega 3 fatty acid-rich diet with the omega 6 fatty acid-rich diet. | lld:pubmed |
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| pubmed-article:2724351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2724351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2724351 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2724351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2724351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2724351 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2724351 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:2724351 | pubmed:author | pubmed-author:CampbellT CTC | lld:pubmed |
| pubmed-article:2724351 | pubmed:author | pubmed-author:KinsellaJ EJE | lld:pubmed |
| pubmed-article:2724351 | pubmed:author | pubmed-author:PetersonF JFJ | lld:pubmed |
| pubmed-article:2724351 | pubmed:author | pubmed-author:RoebuckB DBD | lld:pubmed |
| pubmed-article:2724351 | pubmed:author | pubmed-author:O'ConnorT PTP | lld:pubmed |
| pubmed-article:2724351 | pubmed:author | pubmed-author:LokeshBB | lld:pubmed |
| pubmed-article:2724351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2724351 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:2724351 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:2724351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2724351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2724351 | pubmed:pagination | 858-63 | lld:pubmed |
| pubmed-article:2724351 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2724351 | pubmed:meshHeading | pubmed-meshheading:2724351-... | lld:pubmed |
| pubmed-article:2724351 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2724351 | pubmed:articleTitle | Effect of dietary omega-3 and omega-6 fatty acids on development of azaserine-induced preneoplastic lesions in rat pancreas. | lld:pubmed |
| pubmed-article:2724351 | pubmed:affiliation | Division of Nutritional Sciences, Cornell University, Ithaca, NY. | lld:pubmed |
| pubmed-article:2724351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2724351 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2724351 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2724351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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