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pubmed-article:2715313pubmed:abstractTextBody fluids suspected of bacterial infection were cultured and examined for the presence of D-lactic acid, a specific bacterial metabolite. We examined 206 patients and 264 specimens. D-Lactic acid was found in concentrations of greater than or equal to 0.15 mM in 11 of 11 infected and 6 of 40 noninfected ascitic fluids, 6 of 6 infected and 4 of 33 noninfected pleural fluids, 4 of 4 infected and 0 of 13 noninfected synovial fluids, and 26 of 27 infected and 2 of 130 noninfected cerebrospinal fluids. The overall sensitivity was 79.7%, and the specificity was 99.5% when the D-lactic acid concentration was at least 0.15 mM. The most important clinical utility of the D-lactic acid measurement appears to be for patients with bacterial infection in various body compartments and in patients who have already received antimicrobial therapy. An elevation in D-lactic acid may indicate the presence of bacterial infection even when cultures are negative.lld:pubmed
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pubmed-article:2715313pubmed:authorpubmed-author:SmithS MSMlld:pubmed
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pubmed-article:2715313pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:2715313pubmed:articleTitleD-lactic acid measurements in the diagnosis of bacterial infections.lld:pubmed
pubmed-article:2715313pubmed:affiliationMedical Service, Veterans Administration Medical Center, East Orange, New Jersey 07019.lld:pubmed
pubmed-article:2715313pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2715313pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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