| pubmed-article:2707163 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0013336 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0169964 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2707163 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2707163 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2707163 | pubmed:dateCreated | 1989-6-6 | lld:pubmed |
| pubmed-article:2707163 | pubmed:abstractText | A new mutant GH-deficient dwarf rat has been used to study the effects of iv infusions of human GH (hGH) and recombinant human insulin-like growth factor I (hIGF-I). This animal has only about 5% of normal pituitary GH content, low circulating GH levels, and no regular GH surges. The defect seems to be specific for GH. Infusions of hIGF-I at 180 micrograms/day for 9 days elevated serum IGF-I concentrations significantly over those in the saline-infused controls (713 +/- 20 ng/ml vs. 395 +/- 31 ng/ml); hGH infusions did not raise IGF-I levels significantly (435 +/- 20 ng/ml). Gel filtration of serum samples showed that the high-dose hIGF-I infusions increased free IGF concentrations, without apparently altering the pattern of IGF-I binding whereas hGH infusions increased the amount of high mol wt IGF-I binding protein. Neither IGF-I nor hGH infusions affected the small amounts of rat GH present in the dwarf rat pituitary glands. Continuous iv infusions of hGH (200 mU/day for 9 days) stimulated body wt gain (2.1 +/- 0.2 g/day) and bone growth (96 +/- 9 microns/day) significantly compared to saline-infused dwarf rats (1.2 +/- 0.3 g/day and 43 +/- 3 microns/day). Infusions of hIGF-I at 180 micrograms/day produced a body wt gain (2.1 +/- 0.5 g/day) similar to that seen in the hGH-infused group but a significantly smaller stimulation of bone growth (63 +/- 3 microns/day). Infusion of a 5-fold lower dose of hIGF-I (36 micrograms/day for 9 days) had no effect on body wt or bone growth. Food intake was unaffected by either hGH or hIGF-I infusions. The pattern of tissue growth was affected differentially by hGH and IGF-I infusions that produced the same overall body wt gain. hGH induced a relatively proportional growth in most of the organs studied, whereas hIGF-I infusion at 180 micrograms/day stimulated a disproportionately greater growth of the kidney, adrenals, and spleen. In some of the animals, tissues were extracted for RIA of IGF-I; the amounts of IGF-I in the liver were similar in control, hGH, or IGF-I-infused animals, whereas kidney and adrenals from IGF-I infused animals contained larger amounts of immunoreactive IGF-I than did those tissues from hGH-treated rats. Thus, both hGH and hIGF-I can promote growth in the mutant dwarf rat, but they differ both quantitatively and qualitatively in their pattern of actions. | lld:pubmed |
| pubmed-article:2707163 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2707163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2707163 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2707163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2707163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2707163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2707163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2707163 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2707163 | pubmed:month | May | lld:pubmed |
| pubmed-article:2707163 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:2707163 | pubmed:author | pubmed-author:FryklundLL | lld:pubmed |
| pubmed-article:2707163 | pubmed:author | pubmed-author:RobinsonI CIC | lld:pubmed |
| pubmed-article:2707163 | pubmed:author | pubmed-author:ClarkR GRG | lld:pubmed |
| pubmed-article:2707163 | pubmed:author | pubmed-author:SkottnerAA | lld:pubmed |
| pubmed-article:2707163 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2707163 | pubmed:volume | 124 | lld:pubmed |
| pubmed-article:2707163 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2707163 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2707163 | pubmed:pagination | 2519-26 | lld:pubmed |
| pubmed-article:2707163 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:2707163 | pubmed:meshHeading | pubmed-meshheading:2707163-... | lld:pubmed |
| pubmed-article:2707163 | pubmed:meshHeading | pubmed-meshheading:2707163-... | lld:pubmed |
| pubmed-article:2707163 | pubmed:meshHeading | pubmed-meshheading:2707163-... | lld:pubmed |
| pubmed-article:2707163 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2707163 | pubmed:articleTitle | Growth responses in a mutant dwarf rat to human growth hormone and recombinant human insulin-like growth factor I. | lld:pubmed |
| pubmed-article:2707163 | pubmed:affiliation | Kabi Peptide Hormones, Research and Development, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:2707163 | pubmed:publicationType | Journal Article | lld:pubmed |
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