| pubmed-article:2704733 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2704733 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2704733 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2704733 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:2704733 | lifeskim:mentions | umls-concept:C0017645 | lld:lifeskim |
| pubmed-article:2704733 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:2704733 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2704733 | pubmed:dateCreated | 1989-5-24 | lld:pubmed |
| pubmed-article:2704733 | pubmed:abstractText | We have identified an erythroid-specific enhancer element far upstream of the human "beta-like globin" genes, at 10.2-11.0 kilobases 5' of the embryonic epsilon-globin gene, and thus at 53-54 kilobases 5' of the adult beta-globin gene. It is capable of enhancing the expression of a cis-linked test gene by up to 300-fold. This enhancer element is apparently developmental-stage-independent, as it is functional at the embryonic and the adult developmental stages in erythroid cells that are expressing the respective beta-like globin genes. The enhancer and globin promoter sequences work in synergy and are capable of conferring on a cis-linked gene the high transcriptional efficiency (enhancer function), erythroid specificity (enhancer and promoter functions), and developmental-stage specificity (promoter function) that are characteristic of the in vivo transcription of the beta-like globin genes in erythroid cells. | lld:pubmed |
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| pubmed-article:2704733 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2704733 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2704733 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2704733 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2704733 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2704733 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2704733 | pubmed:author | pubmed-author:LondonI MIM | lld:pubmed |
| pubmed-article:2704733 | pubmed:author | pubmed-author:JoöG BGB | lld:pubmed |
| pubmed-article:2704733 | pubmed:author | pubmed-author:SolomonW BWB | lld:pubmed |
| pubmed-article:2704733 | pubmed:author | pubmed-author:TuanD YDY | lld:pubmed |
| pubmed-article:2704733 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2704733 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2704733 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2704733 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2704733 | pubmed:pagination | 2554-8 | lld:pubmed |
| pubmed-article:2704733 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2704733 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2704733 | pubmed:articleTitle | An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes. | lld:pubmed |
| pubmed-article:2704733 | pubmed:affiliation | Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge 02139. | lld:pubmed |
| pubmed-article:2704733 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2704733 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2704733 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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