| pubmed-article:2677048 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2677048 | lifeskim:mentions | umls-concept:C1149837 | lld:lifeskim |
| pubmed-article:2677048 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2677048 | pubmed:dateCreated | 1989-11-1 | lld:pubmed |
| pubmed-article:2677048 | pubmed:abstractText | The effects of exercise and a physiological increase in plasma insulin concentration on muscle lipoprotein lipase activity (mLPLA), leg exchange of glucose, and serum lipoprotein levels were investigated in healthy young men. During euglycemic hyperinsulinemia (n = 7) at 44 mU.liter-1, m-LPLA in non-exercised muscle decreased from 30 +/- 7.4 mU.g-1 wet weight (w.w.) (mean +/- SE) to 19 +/- 3.3 (P less than 0.05). Furthermore, the decrease in m-LPLA correlated closely (r = 0.97, P less than 0.05) with the increase in leg glucose uptake. Moreover, basal m-LPLA correlated with the insulin-induced increase in leg glucose uptake (r = 0.93, P less than 0.05). In the control group (n = 6) in which saline was infused in place of insulin and glucose, m-LPLA in nonexercised muscle did not change with time. No change in m-LPLA was observed immediately after one-legged knee extension exercise, but 4 h after exercise m-LPLA was higher (P less than 0.05) in the exercised thigh (47 +/- 17.8 mU.g-1 w.w.) compared with the contralateral nonexercised thigh (29 +/- 6.3 mU.g-1 w.w.). This difference was not found 8 h after exercise. The triacylglycerol content of serum lipoproteins decreased during insulin infusion. It is concluded that in contrast to the effect on adipose tissue, physiological concentrations of insulin decrease m-LPLA in proportion to the effect of insulin on muscle glucose uptake, while muscle contractions cause a local, delayed, and transient increase in m-LPLA. Further-more, basal m-LPLA is an indicator of muscle insulin sensitivity. | lld:pubmed |
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| pubmed-article:2677048 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2677048 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2677048 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2677048 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2677048 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2677048 | pubmed:author | pubmed-author:LithellHH | lld:pubmed |
| pubmed-article:2677048 | pubmed:author | pubmed-author:RichterE AEA | lld:pubmed |
| pubmed-article:2677048 | pubmed:author | pubmed-author:KiensBB | lld:pubmed |
| pubmed-article:2677048 | pubmed:author | pubmed-author:MikinesK JKJ | lld:pubmed |
| pubmed-article:2677048 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2677048 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:2677048 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2677048 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2677048 | pubmed:pagination | 1124-9 | lld:pubmed |
| pubmed-article:2677048 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2677048 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2677048 | pubmed:articleTitle | Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. | lld:pubmed |
| pubmed-article:2677048 | pubmed:affiliation | August Krogh Institute, University of Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:2677048 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2677048 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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