| pubmed-article:2674658 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2674658 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:2674658 | lifeskim:mentions | umls-concept:C0681698 | lld:lifeskim |
| pubmed-article:2674658 | lifeskim:mentions | umls-concept:C1414461 | lld:lifeskim |
| pubmed-article:2674658 | lifeskim:mentions | umls-concept:C1333237 | lld:lifeskim |
| pubmed-article:2674658 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2674658 | pubmed:dateCreated | 1989-10-16 | lld:pubmed |
| pubmed-article:2674658 | pubmed:abstractText | Resistance transfer factors are natural conjugative plasmids encoding antibiotic resistance. Some also encode mutagenic DNA repair genes giving resistance to DNA damage and induced mutagenesis. It has been shown that antibiotic resistance has been acquired by recent transposition events; however, we show here that mutagenic repair genes existed much earlier on these types of plasmids. Conjugative plasmids from eight incompatibility groups from the Murray collection of 'pre-antibiotic era' enterobacteria were tested for complementation of mutagenic repair-deficient Escherichia coli umuC36. Although none of these plasmids carry transposon-encoded drug resistance genes, IncI1 and IncB plasmids were identified which restored ultraviolet resistance and induced mutability to umuC36 mutants. Furthermore they increased the UV resistance and induced mutability of wild-type E. coli, Klebsiella aerogenes and Citrobacter intermedius, thus showing that they could confer a general selective advantage to a variety of hosts. Like known mutagenic repair genes, complementation by these plasmid genes required the SOS response of the host cell. Nucleotide hybridisation showed that these plasmids harboured sequences similar to the impCAB locus, the mutagenic repair operon of modern-day IncI1 plasmids. The evolution of mutagenic repair genes is discussed. | lld:pubmed |
| pubmed-article:2674658 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2674658 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2674658 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2674658 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2674658 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2674658 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2674658 | pubmed:issn | 0026-8925 | lld:pubmed |
| pubmed-article:2674658 | pubmed:author | pubmed-author:ThomasS MSM | lld:pubmed |
| pubmed-article:2674658 | pubmed:author | pubmed-author:SedgwickS GSG | lld:pubmed |
| pubmed-article:2674658 | pubmed:author | pubmed-author:StrikePP | lld:pubmed |
| pubmed-article:2674658 | pubmed:author | pubmed-author:HughesV MVM | lld:pubmed |
| pubmed-article:2674658 | pubmed:author | pubmed-author:LodwickDD | lld:pubmed |
| pubmed-article:2674658 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2674658 | pubmed:volume | 218 | lld:pubmed |
| pubmed-article:2674658 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2674658 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2674658 | pubmed:pagination | 323-9 | lld:pubmed |
| pubmed-article:2674658 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:meshHeading | pubmed-meshheading:2674658-... | lld:pubmed |
| pubmed-article:2674658 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2674658 | pubmed:articleTitle | Mutagenic DNA repair genes on plasmids from the 'pre-antibiotic era'. | lld:pubmed |
| pubmed-article:2674658 | pubmed:affiliation | Genetics Division, National Institute for Medical Research, London, UK. | lld:pubmed |
| pubmed-article:2674658 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2674658 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2674658 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2674658 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2674658 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2674658 | lld:pubmed |
