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| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0009402 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0017185 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0016360 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0023413 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0282461 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2674331 | lifeskim:mentions | umls-concept:C0023981 | lld:lifeskim |
| pubmed-article:2674331 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2674331 | pubmed:dateCreated | 1989-10-26 | lld:pubmed |
| pubmed-article:2674331 | pubmed:abstractText | A total of 343 patients with previously untreated metastatic measurable colorectal carcinoma were studied to evaluate the impact on toxicity, response, and survival of leucovorin-modulated fluorouracil (5-FU). A maximally tolerated intravenous bolus loading course regimen of 5-FU alone (500 mg/m2 x 5 days every 4 weeks with 25 mg/m2 escalation) was compared with a high-dose leucovorin regimen (600 mg/m2 of 5-FU with 500 mg/m2 of leucovorin weekly for 6 weeks with a 2-week rest) and with a similar low-dose leucovorin regimen (600 mg/m2 of 5-FU with 25 mg/m2 of leucovorin weekly for 6 weeks with a 2-week rest). The dose-limiting toxicity for the two 5-FU and leucovorin regimens was gastrointestinal, specifically diarrhea; severe diarrhea was seen frequently, and treatment-related toxicity was implicated in the demise of 11 of the patients (5%). Significant improvements in response rates were observed with a response rate of 33 of 109 (30.3%) on the high-dose leucovorin regimen (P less than .01 v control); 13 of 107 (12.1%) on the 5-FU control; and 21 of 112 (18.8%) on the low-dose leucovorin regimen. A trend toward longer survival in the 5-FU plus high-dose leucovorin regimen was observed. In this study, leucovorin was shown to significantly enhance the therapeutic effect of 5-FU in metastatic colorectal carcinoma. | lld:pubmed |
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| pubmed-article:2674331 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2674331 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2674331 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2674331 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2674331 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2674331 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2674331 | pubmed:issn | 0732-183X | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:GreenM DMD | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:MayerR JRJ | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:HerreraLL | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:MuggiaF MFM | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:DouglassH... | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:RussellDD | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:BrucknerH WHW | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:StableinD MDM | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:SchinellaRR | lld:pubmed |
| pubmed-article:2674331 | pubmed:author | pubmed-author:PetrelliNN | lld:pubmed |
| pubmed-article:2674331 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2674331 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:2674331 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2674331 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2674331 | pubmed:pagination | 1419-26 | lld:pubmed |
| pubmed-article:2674331 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2674331 | pubmed:meshHeading | pubmed-meshheading:2674331-... | lld:pubmed |
| pubmed-article:2674331 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2674331 | pubmed:articleTitle | The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group. | lld:pubmed |
| pubmed-article:2674331 | pubmed:affiliation | Roswell Park Memorial Institute, Buffalo, NY. | lld:pubmed |
| pubmed-article:2674331 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2674331 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2674331 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2674331 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:2674331 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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