| pubmed-article:2672619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C0028606 | lld:lifeskim |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C0348026 | lld:lifeskim |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C0022877 | lld:lifeskim |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C0449851 | lld:lifeskim |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:2672619 | lifeskim:mentions | umls-concept:C0336791 | lld:lifeskim |
| pubmed-article:2672619 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2672619 | pubmed:dateCreated | 1989-9-26 | lld:pubmed |
| pubmed-article:2672619 | pubmed:abstractText | The acceptance of nucleic acid probes as diagnostic tools for the clinical laboratory has been hampered by a number of factors, including laborious techniques and limited sensitivity. The focus of this review is on the recent development of amplification techniques to enhance the signal generated by nucleic acid-based detection systems. Three general areas are discussed: (1) amplification of target sequences using the polymerase chain reaction or the transcript amplification system, (2) amplification of the probe sequences using Q beta replicase, and (3) amplification of probe-generated signals with compound or "Christmas tree" probes. The hope of these new technologies is to simplify yet improve on the sensitivity of nucleic acid-based tests to enable them to attain a more prominent place in the diagnostic repertoire of the clinical laboratory. | lld:pubmed |
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| pubmed-article:2672619 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2672619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2672619 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2672619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2672619 | pubmed:issn | 0044-0086 | lld:pubmed |
| pubmed-article:2672619 | pubmed:author | pubmed-author:LandryM LML | lld:pubmed |
| pubmed-article:2672619 | pubmed:author | pubmed-author:PersingD HDH | lld:pubmed |
| pubmed-article:2672619 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2672619 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:2672619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2672619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2672619 | pubmed:pagination | 159-71 | lld:pubmed |
| pubmed-article:2672619 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2672619 | pubmed:meshHeading | pubmed-meshheading:2672619-... | lld:pubmed |
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| pubmed-article:2672619 | pubmed:meshHeading | pubmed-meshheading:2672619-... | lld:pubmed |
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| pubmed-article:2672619 | pubmed:meshHeading | pubmed-meshheading:2672619-... | lld:pubmed |
| pubmed-article:2672619 | pubmed:articleTitle | In vitro amplification techniques for the detection of nucleic acids: new tools for the diagnostic laboratory. | lld:pubmed |
| pubmed-article:2672619 | pubmed:affiliation | Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510. | lld:pubmed |
| pubmed-article:2672619 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2672619 | pubmed:publicationType | Review | lld:pubmed |
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