pubmed-article:266715 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:266715 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:266715 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
pubmed-article:266715 | lifeskim:mentions | umls-concept:C0031667 | lld:lifeskim |
pubmed-article:266715 | lifeskim:mentions | umls-concept:C0007382 | lld:lifeskim |
pubmed-article:266715 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
pubmed-article:266715 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:266715 | pubmed:dateCreated | 1977-7-29 | lld:pubmed |
pubmed-article:266715 | pubmed:abstractText | The results of crosslinking experiments with dimethyl suberimidate and gel filtration binding studies are used to delineate a detailed model for phospholipase A2(phosphatide 2-acyl-hydrolase, EC 3.1.1.4) action in the presence of Ca2+ on mixed micelles of Triton X-100 and phospholipid. Important features of the "dual-phospholipid" model are: (i) the use of the nonionic surfactant as an inert matrix that may influence lipid conformation but does not interact with the enzyme; (ii) the involvement of two lipid molecules in a single cycle of catalysis as an explanation for the "surface dilution" phenomenon; (iii) the requirement of an ordered reaction whereby divalent metal ion binds prior to phospholipid binding; and (iv) the induction by lipid substrate of an asymmetric dimer structure for the enzyme. | lld:pubmed |
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pubmed-article:266715 | pubmed:language | eng | lld:pubmed |
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pubmed-article:266715 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:266715 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:266715 | pubmed:month | May | lld:pubmed |
pubmed-article:266715 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:266715 | pubmed:author | pubmed-author:RobertsM FMF | lld:pubmed |
pubmed-article:266715 | pubmed:author | pubmed-author:DennisE AEA | lld:pubmed |
pubmed-article:266715 | pubmed:author | pubmed-author:DeemsR ARA | lld:pubmed |
pubmed-article:266715 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:266715 | pubmed:volume | 74 | lld:pubmed |
pubmed-article:266715 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:266715 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:266715 | pubmed:pagination | 1950-4 | lld:pubmed |
pubmed-article:266715 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:266715 | pubmed:year | 1977 | lld:pubmed |
pubmed-article:266715 | pubmed:articleTitle | Dual role of interfacial phospholipid in phospholipase A2 catalysis. | lld:pubmed |
pubmed-article:266715 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:266715 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:266715 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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