| pubmed-article:2664784 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2664784 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2664784 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2664784 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:2664784 | lifeskim:mentions | umls-concept:C0029463 | lld:lifeskim |
| pubmed-article:2664784 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2664784 | lifeskim:mentions | umls-concept:C0042890 | lld:lifeskim |
| pubmed-article:2664784 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:2664784 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:2664784 | pubmed:dateCreated | 1989-8-16 | lld:pubmed |
| pubmed-article:2664784 | pubmed:abstractText | Monoclonal antibodies were elicited to membrane constituents of the osteoblastic human osteosarcoma cell line Saos-2. Two types of antibody reactivities were characterized: one group of antibodies identified fibroblastic and osteoblastic cultured cells, whereas the other group was specific for the parent cell line, Saos-2. Primary endothelial cells and hepatoma cells were not recognized by either group of antibodies. Through indirect immunofluorescent microscopy, the Saos-2-specific antigen was demonstrated to reside on the surface of these osteosarcoma cells. Metabolic radiolabeling of cultured Saos-2 cells and subsequent immunoprecipitation, electrophoretic separation, and autoradiography revealed this protein to have a Mr of 80,000. Similar experiments in the presence of hormones showed that the expression of this cell surface protein was influenced in an opposing fashion by the bone-regulating hormones parathyroid hormone and vitamin D. Vitamin D stimulated expression by 300%, whereas parathyroid hormone depressed expression by 50%. Thus, Saos-2 human osteoblastic cells demonstrate hormonal regulation through an apparently specific membrane protein. | lld:pubmed |
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| pubmed-article:2664784 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2664784 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2664784 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2664784 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2664784 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2664784 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2664784 | pubmed:author | pubmed-author:MannK GKG | lld:pubmed |
| pubmed-article:2664784 | pubmed:author | pubmed-author:TracyR PRP | lld:pubmed |
| pubmed-article:2664784 | pubmed:author | pubmed-author:ShullSS | lld:pubmed |
| pubmed-article:2664784 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2664784 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2664784 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2664784 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2664784 | pubmed:pagination | 5405-9 | lld:pubmed |
| pubmed-article:2664784 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2664784 | pubmed:meshHeading | pubmed-meshheading:2664784-... | lld:pubmed |
| pubmed-article:2664784 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2664784 | pubmed:articleTitle | Identification of a vitamin D-responsive protein on the surface of human osteosarcoma cells. | lld:pubmed |
| pubmed-article:2664784 | pubmed:affiliation | Department of Biochemistry, University of Vermont Medical College, Burlington 05405. | lld:pubmed |
| pubmed-article:2664784 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2664784 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2664784 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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