| pubmed-article:2663012 | pubmed:abstractText | Based on our experience in 82 liver transplant procedures performed without using a bypass-technique, we report on our current perioperative anaesthetic management. Preoperative plasma exchange with fresh frozen plasma proved very effective in 16 patients with severe coagulation defects, leading to a significant increase in prothrombin time from 27 to 55%. Intra- and postoperative haemodynamic profiles of 48 patients are presented. Baseline measurements revealed a hyperdynamic circulatory state with elevated cardiac index (CI) and heart rate in all patients. During the anhepatic phase CI and mean arterial pressure (MAP) were persistently lowered. Immediately after reperfusion of the graft, reflux of the stagnant venous content induced a significant increase in CI and led to a moderate elevation of pulmonary artery pressure. MAP showed a rather slow recovery, but was within the normal range at the end of surgery. Oxygen consumption index, which was significantly lowered during the anhepatic period, excessively increased after reperfusion of the graft. | lld:pubmed |
