| pubmed-article:2639728 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2639728 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2639728 | lifeskim:mentions | umls-concept:C0009375 | lld:lifeskim |
| pubmed-article:2639728 | lifeskim:mentions | umls-concept:C0023413 | lld:lifeskim |
| pubmed-article:2639728 | lifeskim:mentions | umls-concept:C0039669 | lld:lifeskim |
| pubmed-article:2639728 | lifeskim:mentions | umls-concept:C0049315 | lld:lifeskim |
| pubmed-article:2639728 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:2639728 | lifeskim:mentions | umls-concept:C0439836 | lld:lifeskim |
| pubmed-article:2639728 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2639728 | pubmed:dateCreated | 1990-8-23 | lld:pubmed |
| pubmed-article:2639728 | pubmed:abstractText | Four hr infusions i.v. of [6RS]5-formyltetrahydrofolate ([6RS]5-CHO-H4PteGlu; 500 mg/m2) and [6RS]5-methyltetrahydrofolate ([6RS]5-CH3-H4PteGlu; 500 mg/m2) were compared for their relative effects on expansion of pools of 5,10-methylenetetrahydrofolates (CH2-H4PteGlun) and tetrahydrofolates (H4PteGlun) in two human colon adenocarcinoma xenografts in mice. Expansion of these pools by 253-661% of control and increase in predominance of di-, tri-, and tetra-glutamate species were observed during [6RS]5-CHO-H4PteGlu infusion. In contrast, only modest pool size expansion (148-164% of control) and limited modulation of polyglutamate species were detected in four tumor lines during infusion with [6RS]5-CH3-H4PteGlu. The data suggest that [6RS]5-CH3-H4PteGlu is less effective than [6RS]5-CHO-H4PteGlu as a precursor for pools of CH2-H4PteGlun and H4PteGlun in colon tumors. | lld:pubmed |
| pubmed-article:2639728 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2639728 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2639728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2639728 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2639728 | pubmed:issn | 0955-3541 | lld:pubmed |
| pubmed-article:2639728 | pubmed:author | pubmed-author:HoughtonP JPJ | lld:pubmed |
| pubmed-article:2639728 | pubmed:author | pubmed-author:WainerI WIW | lld:pubmed |
| pubmed-article:2639728 | pubmed:author | pubmed-author:HoughtonJ AJA | lld:pubmed |
| pubmed-article:2639728 | pubmed:author | pubmed-author:WilliamsL GLG | lld:pubmed |
| pubmed-article:2639728 | pubmed:author | pubmed-author:CheshireP JPJ | lld:pubmed |
| pubmed-article:2639728 | pubmed:author | pubmed-author:JadaudPP | lld:pubmed |
| pubmed-article:2639728 | pubmed:author | pubmed-author:de GraafS SSS | lld:pubmed |
| pubmed-article:2639728 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2639728 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:2639728 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2639728 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2639728 | pubmed:pagination | 167-74 | lld:pubmed |
| pubmed-article:2639728 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:meshHeading | pubmed-meshheading:2639728-... | lld:pubmed |
| pubmed-article:2639728 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2639728 | pubmed:articleTitle | Comparison of the conversion of 5-formyltetrahydrofolate and 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon tumors. | lld:pubmed |
| pubmed-article:2639728 | pubmed:affiliation | Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38101. | lld:pubmed |
| pubmed-article:2639728 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2639728 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2639728 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
