| pubmed-article:2635886 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2635886 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:2635886 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:2635886 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:2635886 | lifeskim:mentions | umls-concept:C0068527 | lld:lifeskim |
| pubmed-article:2635886 | lifeskim:mentions | umls-concept:C0242656 | lld:lifeskim |
| pubmed-article:2635886 | lifeskim:mentions | umls-concept:C0681890 | lld:lifeskim |
| pubmed-article:2635886 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2635886 | pubmed:dateCreated | 1989-9-13 | lld:pubmed |
| pubmed-article:2635886 | pubmed:abstractText | We assessed the value of urinary neopterin concentrations for prognosis of disease progression in HIV-1-infected patients. Sixty-eight anti-HIV-1 seropositive homosexuals with lymphadenopathy syndrome were tested for urinary neopterin and T-cell subset counts in 1982-83, and the incidence rate at which they developed acquired immunodeficiency syndrome (AIDS) between then and May 1988 was evaluated. Overall, 21 of 68 (30.9%) cases progressed to AIDS, with a yearly progression rate of 4-9%. The predictive value of urinary neopterin concentrations was higher (P = 0.0042) than that of CD4+ T-cell counts (P = 0.015) or the CD4+/CD8+ T-cell ratio (P = 0.022). Counts of CD8+ T-cells failed to show predictive significance (P = 0.29). Similarly, multivariate-regression analysis indicated that neopterin concentrations and CD4+ T-cell numbers were significant copredictors. Produced by human macrophages activated by interferon gamma, neopterin is thus a marker of macrophage activation via T cells. We conclude that these data demonstrate a correlation between the amount of T-cell-macrophage activation, as measured by urinary neopterin concentrations, and the progression of the disease. | lld:pubmed |
| pubmed-article:2635886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2635886 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2635886 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2635886 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2635886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2635886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2635886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2635886 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2635886 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2635886 | pubmed:issn | 0009-9147 | lld:pubmed |
| pubmed-article:2635886 | pubmed:author | pubmed-author:FuchsDD | lld:pubmed |
| pubmed-article:2635886 | pubmed:author | pubmed-author:SpiraT JTJ | lld:pubmed |
| pubmed-article:2635886 | pubmed:author | pubmed-author:HauserEE | lld:pubmed |
| pubmed-article:2635886 | pubmed:author | pubmed-author:WernerE RER | lld:pubmed |
| pubmed-article:2635886 | pubmed:author | pubmed-author:WachterHH | lld:pubmed |
| pubmed-article:2635886 | pubmed:author | pubmed-author:ReibneggerGG | lld:pubmed |
| pubmed-article:2635886 | pubmed:author | pubmed-author:FelmayerG WGW | lld:pubmed |
| pubmed-article:2635886 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2635886 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:2635886 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2635886 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2635886 | pubmed:pagination | 1746-9 | lld:pubmed |
| pubmed-article:2635886 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:meshHeading | pubmed-meshheading:2635886-... | lld:pubmed |
| pubmed-article:2635886 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2635886 | pubmed:articleTitle | Neopterin as a predictive marker for disease progression in human immunodeficiency virus type 1 infection. | lld:pubmed |
| pubmed-article:2635886 | pubmed:affiliation | Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria. | lld:pubmed |
| pubmed-article:2635886 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2635886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2635886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2635886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2635886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2635886 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2635886 | lld:pubmed |
