| pubmed-article:2615850 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0020433 | lld:lifeskim |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:2615850 | lifeskim:mentions | umls-concept:C0089605 | lld:lifeskim |
| pubmed-article:2615850 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2615850 | pubmed:dateCreated | 1990-3-1 | lld:pubmed |
| pubmed-article:2615850 | pubmed:abstractText | Recently, a mutant rat strain was described with a genetic defect for the biliary excretion of organic anions (TR-rats). To determine the possible heterogeneity of the transport systems in liver, intestine and kidney we investigated the transport of the anion 1-naphthol-beta-D-glucuronide (1-NG) in isolated vascularly perfused organ preparations of the rat liver, intestine and kidney of both Wistar rats and TR- rats. 1-NG was administered as such (liver and kidney experiments) or formed intracellularly from 1-naphthol (1-N) (liver and gut experiments). Independent of the type of exposure to 1-NG, the biliary excretion was considerably impaired in TR- rats. In the intestine the total appearance and the vascular/luminal distribution pattern of 1-NG were not significantly different from the values in control rats. Furthermore, no significant disturbance was found with respect to the renal clearance of 1-NG in the TR- rat when compared with the Wistar rat. Thus, the genetic defect in the TR- rat is restricted to an impaired hepatobiliary excretion of 1-NG and does not affect the excretory systems of the intestine and kidney. These results suggest that the excretion of 1-NG by the liver, intestine and kidney involves distinct organ-specific transport systems. | lld:pubmed |
| pubmed-article:2615850 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2615850 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2615850 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2615850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2615850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2615850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2615850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2615850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2615850 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2615850 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2615850 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2615850 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:2615850 | pubmed:author | pubmed-author:JansenP LPL | lld:pubmed |
| pubmed-article:2615850 | pubmed:author | pubmed-author:NoordhoekJJ | lld:pubmed |
| pubmed-article:2615850 | pubmed:author | pubmed-author:KosterA SAS | lld:pubmed |
| pubmed-article:2615850 | pubmed:author | pubmed-author:de VriesM HMH | lld:pubmed |
| pubmed-article:2615850 | pubmed:author | pubmed-author:RedegeldF AFA | lld:pubmed |
| pubmed-article:2615850 | pubmed:author | pubmed-author:Oude... | lld:pubmed |
| pubmed-article:2615850 | pubmed:author | pubmed-author:de HaanJ GJG | lld:pubmed |
| pubmed-article:2615850 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2615850 | pubmed:volume | 340 | lld:pubmed |
| pubmed-article:2615850 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2615850 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2615850 | pubmed:pagination | 588-92 | lld:pubmed |
| pubmed-article:2615850 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:meshHeading | pubmed-meshheading:2615850-... | lld:pubmed |
| pubmed-article:2615850 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2615850 | pubmed:articleTitle | Hepatic, intestinal and renal transport of 1-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia. | lld:pubmed |
| pubmed-article:2615850 | pubmed:affiliation | Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:2615850 | pubmed:publicationType | Journal Article | lld:pubmed |
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