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pubmed-article:2612567pubmed:abstractTextQuantitative autoradiographic analysis revealed changes in [3H]flunitrazepam (a benzodiazepine agonist) binding in the anterior hypothalamus nucleus, the medial preoptic area and the cortico-medial amygdala nucleus following in vivo estradiol. The administration of 4 mg of progesterone, but not 1 mg, increased the binding of [3H]flunitrazepam in the basolateral amygdaloid nucleus and in the oriens-pyramidalis CA1 layer of the hippocampus. Exposure of brain sections in vitro to the potent, naturally occurring progesterone metabolite, 3 alpha-hydroxy-5 alpha-dihydroprogesterone, induced GABA-dependent changes in flunitrazepam binding, similar to the changes induced by progesterone, thus suggesting that different steroid mechanisms are implicated in the control of flunitrazepam binding.lld:pubmed
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pubmed-article:2612567pubmed:articleTitleDifferential modulation of [3H]flunitrazepam binding in female rat brain by sex steroid hormones.lld:pubmed
pubmed-article:2612567pubmed:affiliationZoology Laboratory, University of Calabria, Italy.lld:pubmed
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