| pubmed-article:2610261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2610261 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:2610261 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2610261 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2610261 | lifeskim:mentions | umls-concept:C0227578 | lld:lifeskim |
| pubmed-article:2610261 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:2610261 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:2610261 | pubmed:issue | 6 Pt 1 | lld:pubmed |
| pubmed-article:2610261 | pubmed:dateCreated | 1990-2-12 | lld:pubmed |
| pubmed-article:2610261 | pubmed:abstractText | The biochemical and Ca2+ transport pathways involved in generating the hormone-evoked Ca2+ signal are reported to be influenced by pH. The present study was designed to determine the effect of extracellular pH (pHo) and intracellular pH (pHi) on hormone-stimulated Ca2+ transport. We used rat pancreatic acini and measured free cytosolic Ca2+ concentration ([Ca2+]i) with fura-2, pHi with 2,7-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF), and Ca2+ fluxes with 45Ca2+. In the presence of external Ca2+, increasing pHo increased steady-state [Ca2+]i during sustained agonist stimulation; in the absence of external Ca2+, this increase in [Ca2+]i did not occur. The addition of an antagonist or blocking plasma membrane Ca2+ influx with La3+ in stimulated cells suspended at pHo 8.2 resulted in a reduction in [Ca2+]i. Increasing pHo increased the rate and extent of 45Ca2+ uptake into stimulated cells and the rate and extent of Ca2+ reloading of intracellular stores. The increased Ca2+ content of the intracellular stores with increased pHo indicated that at physiological pHo and pHi the agonist-mobilizable internal stores are not saturated with Ca2+. Changes in pHo affected pHi. However, changes in pHi at constant pHo had no effect on hormone-evoked [Ca2+]i increase, reduction in [Ca2+]i after hormone stimulation, or reloading of intracellular stores. We conclude that the hormone-activated plasma membrane Ca2+ entry pathway responsible for Ca2+ reloading is directly modulated by external H+. | lld:pubmed |
| pubmed-article:2610261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2610261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2610261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2610261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2610261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2610261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2610261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2610261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2610261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2610261 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2610261 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2610261 | pubmed:author | pubmed-author:MuallemSS | lld:pubmed |
| pubmed-article:2610261 | pubmed:author | pubmed-author:PandolS JSJ | lld:pubmed |
| pubmed-article:2610261 | pubmed:author | pubmed-author:BeekerT GTG | lld:pubmed |
| pubmed-article:2610261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2610261 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:2610261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2610261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2610261 | pubmed:pagination | G917-24 | lld:pubmed |
| pubmed-article:2610261 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2610261 | pubmed:meshHeading | pubmed-meshheading:2610261-... | lld:pubmed |
| pubmed-article:2610261 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2610261 | pubmed:articleTitle | Modulation of agonist-activated calcium influx by extracellular pH in rat pancreatic acini. | lld:pubmed |
| pubmed-article:2610261 | pubmed:affiliation | Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235. | lld:pubmed |
| pubmed-article:2610261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2610261 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2610261 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2610261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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