Linked Life Data

2595456

Source:http://linkedlifedata.com/resource/pubmed/id/2595456

Statements in which the resource exists.
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pubmed-article:2595456pubmed:abstractTextWe have analyzed a line of transgenic mice derived from injection of a cloned human interferon cDNA. This line manifests total male sterility of males carrying the human sequence, while male littermates not harboring the foreign DNA are fertile. All females are fertile. Karyotypes of transgenic animals show 2:12 translocation. The microinjected sequence maps to one of the translocation chromosomes composed of a large portion of chromosome 12 to which has been translocated a segment of chromosome 2. Analysis of the sterile males reveals significant abnormalities of spermatogenesis and faulty chromosome synapsis that involves the translocation chromosomes. These findings show that transfer of foreign DNA into mouse embryos may lead to chromatin breakage and infertility of transgenic animals.lld:pubmed
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pubmed-article:2595456pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2595456pubmed:year1989lld:pubmed
pubmed-article:2595456pubmed:articleTitleAssociation of foreign DNA sequence with male sterility and translocation in a line of transgenic mice.lld:pubmed
pubmed-article:2595456pubmed:affiliationBrookdale Center for Molecular Biology, Mt. Sinai Medical Center, New York, New York 10029.lld:pubmed
pubmed-article:2595456pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2595456pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:2595456pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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