| pubmed-article:2592394 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2592394 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:2592394 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:2592394 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:2592394 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:2592394 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2592394 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:2592394 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2592394 | pubmed:dateCreated | 1990-1-25 | lld:pubmed |
| pubmed-article:2592394 | pubmed:abstractText | A pseudomembranous structure that has the histological characteristics of a foreign-body-like reaction invariably develops at the bone-cement interface in the proximity of resorption of bone around aseptically loosened cemented prostheses. This study was an attempt to implicate polymethylmethacrylate in this resorptive process. Unfractionated peripheral-blood mononuclear cells (consisting of lymphocytes and monocytes) and surface-adherent cells (monocyte-enriched) were prepared from control subjects who did and did not have clinical evidence of osteoarthrosis and from patients who had osteoarthrosis and were having a revision for failure of a cemented hip or knee implant. Cells were cultured for varying periods in the presence and absence of nonpolymerized methacrylate (one to two-micrometer spherules), pulverized polymerized material, or culture chambers that were pre-coated with polymerized cement. Conditioned media that were derived from both methacrylate-stimulated cell populations were shown to contain specific bone-resorbing mediators (interleukin-1, tumor necrosis factor, or prostaglandin E2) and to directly affect bone resorption in 45Ca-labeled murine limb-bone assays. | lld:pubmed |
| pubmed-article:2592394 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2592394 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2592394 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2592394 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2592394 | pubmed:issn | 0021-9355 | lld:pubmed |
| pubmed-article:2592394 | pubmed:author | pubmed-author:AndersonDD | lld:pubmed |
| pubmed-article:2592394 | pubmed:author | pubmed-author:HermanJ HJH | lld:pubmed |
| pubmed-article:2592394 | pubmed:author | pubmed-author:HopsonC NCN | lld:pubmed |
| pubmed-article:2592394 | pubmed:author | pubmed-author:SowderW GWG | lld:pubmed |
| pubmed-article:2592394 | pubmed:author | pubmed-author:AppelA MAM | lld:pubmed |
| pubmed-article:2592394 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2592394 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:2592394 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2592394 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2592394 | pubmed:pagination | 1530-41 | lld:pubmed |
| pubmed-article:2592394 | pubmed:dateRevised | 2010-10-25 | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:meshHeading | pubmed-meshheading:2592394-... | lld:pubmed |
| pubmed-article:2592394 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2592394 | pubmed:articleTitle | Polymethylmethacrylate-induced release of bone-resorbing factors. | lld:pubmed |
| pubmed-article:2592394 | pubmed:affiliation | Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267. | lld:pubmed |
| pubmed-article:2592394 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2592394 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
