| pubmed-article:2589485 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2589485 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:2589485 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:2589485 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:2589485 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:2589485 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:2589485 | lifeskim:mentions | umls-concept:C1527409 | lld:lifeskim |
| pubmed-article:2589485 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2589485 | pubmed:issue | 5 Pt 2 | lld:pubmed |
| pubmed-article:2589485 | pubmed:dateCreated | 1989-12-28 | lld:pubmed |
| pubmed-article:2589485 | pubmed:abstractText | The in vivo action of cyclosporine A (CS) on rat renal cortical mitochondria was investigated. CS (30 mg.kg-1.day-1) given orally to rats for 30 days caused an augmentation of renal mitochondrial oxidative phosphorylation. The ADP-stimulated respiratory rate was increased by 37.0% with glutamate plus malate as respiratory substrates (P less than 0.025) but not with succinate-supported respiration, indicating enhancement of mitochondrial complex I activity. This reaction may be a response to the 32.5% reduction of renal blood (P less than 0.005) in the CS-treated group, possibly serving to maximize ATP synthesis during ischemia. Ligation-induced decreases in renal blood flow also resulted in enhancement of mitochondrial complex I activity. | lld:pubmed |
| pubmed-article:2589485 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2589485 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2589485 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2589485 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2589485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2589485 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2589485 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2589485 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:RajferJJ | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:MillerR LRL | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:GAYD MDM | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:HirschbergRR | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:ParkK SKS | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:LemmiC ACA | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:SikkaS CSC | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:GeesamanBB | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:PelikanP CPC | lld:pubmed |
| pubmed-article:2589485 | pubmed:author | pubmed-author:KoyleMM | lld:pubmed |
| pubmed-article:2589485 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2589485 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:2589485 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2589485 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2589485 | pubmed:pagination | F837-41 | lld:pubmed |
| pubmed-article:2589485 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:meshHeading | pubmed-meshheading:2589485-... | lld:pubmed |
| pubmed-article:2589485 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2589485 | pubmed:articleTitle | Cyclosporine augments renal mitochondrial function in vivo and reduces renal blood flow. | lld:pubmed |
| pubmed-article:2589485 | pubmed:affiliation | Department of Anatomy and Cell Biology, University of California, Los Angeles 90024. | lld:pubmed |
| pubmed-article:2589485 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2589485 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2589485 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
