| pubmed-article:2584704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2584704 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2584704 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2584704 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2584704 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2584704 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2584704 | lifeskim:mentions | umls-concept:C0600531 | lld:lifeskim |
| pubmed-article:2584704 | lifeskim:mentions | umls-concept:C1819464 | lld:lifeskim |
| pubmed-article:2584704 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2584704 | pubmed:dateCreated | 1990-1-5 | lld:pubmed |
| pubmed-article:2584704 | pubmed:abstractText | Incubation of the human U937 histiocytic lymphoma cell line with granulocyte-macrophage colony stimulating factor (GM-CSF) rendered the cells responsive to induction of TNF by LPS. Treatment with IL-6 reduced TNF production in GM-CSF-primed U937 cells. The inhibitory effect was most pronounced (approximately equal to 80%) when IL-6 was added either along with GM-CSF or within the first 3 h of GM-CSF treatment. Both GM-CSF or IL-6 inhibited [3H]TdR uptake in U937 cells, and simultaneous treatment with GM-CSF and IL-6 resulted in an additive inhibitory effect on cell proliferation. However, the inhibition of TNF production could not be explained by the inhibitory effect of IL-6 on cell growth, nor was it due to a reduction in cell viability. An inhibition of TNF production by IL-6 was also demonstrated in cultured human peripheral blood monocytes. Treatment with IL-6 also resulted in a dose-dependent reduction of the 17-kDa TNF band revealed by SDS-PAGE after labeling monocytes with [35S]cysteine and immunoprecipitation with anti-TNF mAb. In addition, treatment with IL-6 resulted in a reduction of monocyte in vitro cytotoxicity for tumor target cells. Finally, in mice sensitized by the administration of Bacillus Calmette-Guérin, the injection of IL-6 significantly reduced the levels of TNF found in the serum upon challenge with LPS. Inasmuch as TNF is known to be an inducer of IL-6, the inhibitory action of IL-6 on TNF production may represent the negative arm of a regulatory circuit. The inhibitory action of IL-6 on TNF production is consistent with a predominantly antiinflammatory role of IL-6 in the intact organism. | lld:pubmed |
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| pubmed-article:2584704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2584704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2584704 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2584704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2584704 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2584704 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2584704 | pubmed:author | pubmed-author:VilcekJJ | lld:pubmed |
| pubmed-article:2584704 | pubmed:author | pubmed-author:AderkaDD | lld:pubmed |
| pubmed-article:2584704 | pubmed:author | pubmed-author:EinDD | lld:pubmed |
| pubmed-article:2584704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2584704 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2584704 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:2584704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2584704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2584704 | pubmed:pagination | 3517-23 | lld:pubmed |
| pubmed-article:2584704 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2584704 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2584704 | pubmed:articleTitle | IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. | lld:pubmed |
| pubmed-article:2584704 | pubmed:affiliation | Department of Microbiology, New York University Medical Center 10016. | lld:pubmed |
| pubmed-article:2584704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2584704 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2584704 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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