| pubmed-article:2582413 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2582413 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2582413 | lifeskim:mentions | umls-concept:C0076560 | lld:lifeskim |
| pubmed-article:2582413 | lifeskim:mentions | umls-concept:C0032176 | lld:lifeskim |
| pubmed-article:2582413 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:2582413 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2582413 | pubmed:dateCreated | 1985-6-25 | lld:pubmed |
| pubmed-article:2582413 | pubmed:abstractText | A monoclonal antibody (C6.7) has been generated against the calcium-replete form of human platelet thrombospondin (TSP). C6.7 is specific for TSP as determined by both competitive radioimmunoassay and immunoprecipitation. This antibody inhibits both thrombin- and A23187-induced aggregation of gel-filtered platelets in a concentration-dependent manner without affecting the secretion of serotonin. The epitope on TSP recognized by C6.7 has been localized to an 18-kDa fragment that is present in mild chymotryptic digests of TSP. This fragment is disulfide-linked to a 120- to 140-kDa fragment in unreduced digests, and both reduction and denaturation are required to separate the 18-kDa peptide from the larger fragments. A 25-kDa heparin binding domain is also present in the chymotryptic digest. However, the 18-kDa peptide is distinct from the heparin binding domain. The amino acid sequence at the NH2 terminus of the 18-kDa fragment is Asp-Thr-Asn-Pro-Thr-Arg-Ala-Gln-Gly-Tyr-. | lld:pubmed |
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| pubmed-article:2582413 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2582413 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2582413 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2582413 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2582413 | pubmed:month | May | lld:pubmed |
| pubmed-article:2582413 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2582413 | pubmed:author | pubmed-author:FrazierW AWA | lld:pubmed |
| pubmed-article:2582413 | pubmed:author | pubmed-author:DixitV MVM | lld:pubmed |
| pubmed-article:2582413 | pubmed:author | pubmed-author:HaverstickD... | lld:pubmed |
| pubmed-article:2582413 | pubmed:author | pubmed-author:GrantG AGA | lld:pubmed |
| pubmed-article:2582413 | pubmed:author | pubmed-author:SantoroS ASA | lld:pubmed |
| pubmed-article:2582413 | pubmed:author | pubmed-author:HennessyS WSW | lld:pubmed |
| pubmed-article:2582413 | pubmed:author | pubmed-author:O'RourkeK MKM | lld:pubmed |
| pubmed-article:2582413 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2582413 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:2582413 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2582413 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2582413 | pubmed:pagination | 3472-6 | lld:pubmed |
| pubmed-article:2582413 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2582413 | pubmed:meshHeading | pubmed-meshheading:2582413-... | lld:pubmed |
| pubmed-article:2582413 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2582413 | pubmed:articleTitle | A monoclonal antibody against human thrombospondin inhibits platelet aggregation. | lld:pubmed |
| pubmed-article:2582413 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2582413 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2582413 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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