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pubmed-article:2581567pubmed:abstractTextJunctional sarcoplasmic reticulum (SR) has been identified in microsomes from canine ventricular muscle by the presence of calsequestrin and ryanodine-sensitive Ca2+ release channels. These properties, however, are not common to cardiac cells from all species. Seiler et al (1) have recently described a high Mr polypeptide in canine junctional SR similar to the spanning protein subunits of skeletal muscle triads. We now report the existence of a polypeptide with the same mobility in SR from rabbit ventricular muscle and show that those cardiac membranes can associate with transverse (T-) tubules from rabbit skeletal muscle in K cacodylate medium. We propose that this polypeptide and the reaction with T-tubules be considered as criteria for the identification of cardiac junctional SR.lld:pubmed
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pubmed-article:2581567pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2581567pubmed:articleTitleA functional identification of cardiac junctional sarcoplasmic reticulum.lld:pubmed
pubmed-article:2581567pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2581567pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed