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pubmed-article:2574646pubmed:abstractTextWe have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappearance curve of serum GH was mono-exponential and the mean half-life was 8.9 min (SD 1.5). This is less than previously reported and has important implications for the performance of GH profiles, which should be performed with 10-15 min sampling intervals, and the calculation of pituitary GH secretion rates.lld:pubmed
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pubmed-article:2574646pubmed:articleTitleThe half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin.lld:pubmed
pubmed-article:2574646pubmed:affiliationEndocrine Unit, Middlesex Hospital, London, UK.lld:pubmed
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