| pubmed-article:2570036 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2570036 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:2570036 | lifeskim:mentions | umls-concept:C0007578 | lld:lifeskim |
| pubmed-article:2570036 | lifeskim:mentions | umls-concept:C0054942 | lld:lifeskim |
| pubmed-article:2570036 | lifeskim:mentions | umls-concept:C1510802 | lld:lifeskim |
| pubmed-article:2570036 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2570036 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2570036 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2570036 | pubmed:dateCreated | 1989-10-3 | lld:pubmed |
| pubmed-article:2570036 | pubmed:abstractText | We examined the mechanisms involved in neutrophil adherence to cultured human umbilical vein endothelial cells (HEC) induced by direct stimulation of the neutrophils by phorbol myristate acetate (PMA), formylmethionyl-leucyl-phenylalanine (FMLP), or the calcium ionophore A23187 (neutrophil-dependent adherence), or by pretreatment of HEC with interleukin-1 (IL-1), tumour necrosis factor (TNF) or lipopolysaccharide (LPS) (endothelial-dependent adherence). Two distinct mechanisms for neutrophil adherence to HEC were demonstrated by performing adherence assays: (i) at 37 degrees versus 4 degrees; (ii) in the presence of Ca2+ only versus Mg2+ only; and (iii) in the presence or absence of monoclonal antibodies (mAb) to the CD11/CD18 adhesion complex of neutrophils. A CD11/CD18-dependent mechanism (i.e. inhibited by anti-CD18 mAb) was identified that was active in the presence of Mg2+ only but not of Ca2+ only, and at 37 degrees but not at 4 degrees. A CD11/CD18-independent mechanism (i.e. not inhibited by anti-CD18 mAb) was active at 4 degrees and at 37 degrees, and in the presence of Ca2+ only and of Mg2+ only. Neutrophil-dependent adherence induced by FMLP or PMA occurred solely via the CD11/CD18-dependent mechanism, whereas endothelial-dependent adherence induced by a 4-hr pretreatment with IL-1, TNF, or LPS involved both CD11/CD18-dependent and/independent mechanisms. CD11/CD18-deficient neutrophils isolated from a patient with leucocyte adherence deficiency (LAD) maintained the ability to adhere to LPS-pretreated HEC in the presence of Ca2+ only, indicating that this mechanism of adherence involves a receptor on the neutrophil distinct from CD11/CD18. Furthermore, the disappearance of the CD11/CD18-independent, but not of the CD11/CD18-dependent mechanism of adherence, in HEC treated with TNF for 24 hr suggests that the two mechanisms of neutrophil adherence also involve distinct inducible endothelial-leucocyte adhesion molecules (E-LAM). | lld:pubmed |
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| pubmed-article:2570036 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2570036 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570036 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2570036 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2570036 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2570036 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:2570036 | pubmed:author | pubmed-author:OchsH DHD | lld:pubmed |
| pubmed-article:2570036 | pubmed:author | pubmed-author:BeattyP GPG | lld:pubmed |
| pubmed-article:2570036 | pubmed:author | pubmed-author:HarlanJ MJM | lld:pubmed |
| pubmed-article:2570036 | pubmed:author | pubmed-author:DobrinaAA | lld:pubmed |
| pubmed-article:2570036 | pubmed:author | pubmed-author:SchwartzB RBR | lld:pubmed |
| pubmed-article:2570036 | pubmed:author | pubmed-author:CarlosT MTM | lld:pubmed |
| pubmed-article:2570036 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2570036 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:2570036 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2570036 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2570036 | pubmed:pagination | 502-8 | lld:pubmed |
| pubmed-article:2570036 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2570036 | pubmed:meshHeading | pubmed-meshheading:2570036-... | lld:pubmed |
| pubmed-article:2570036 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2570036 | pubmed:articleTitle | CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro. | lld:pubmed |
| pubmed-article:2570036 | pubmed:affiliation | Institute of General Pathology, University of Trieste, Italy. | lld:pubmed |
| pubmed-article:2570036 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2570036 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2570036 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2570036 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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