| pubmed-article:2564289 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C0086439 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C0011685 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:2564289 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:2564289 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2564289 | pubmed:dateCreated | 1989-4-25 | lld:pubmed |
| pubmed-article:2564289 | pubmed:abstractText | 1. The effects of acute and chronic (14 day) administration of the noradrenaline uptake inhibitor, desipramine (DMI), on the thermogenic responses to clonidine in reserpine-treated mice, and on the hypothermic and hypoactivity responses to the alpha 2-agonist, UK-14,304, in untreated mice were examined. 2. Taking the capacity of DMI to delay the onset of reserpine-induced hypothermia as an indicator of noradrenaline (NA) uptake inhibition, the lowest dose of DMI to inhibit uptake significantly for 12 h in the mouse was shown to be between 10 and 20 mg kg-1 orally. 3. Chronic (every 12 h for 14 days), but not acute treatment with DMI (15 mg kg-1, orally), attenuated the thermogenic responses to low doses (0.02-0.225 mg kg-1, i.p.) of clonidine (injected 20 h after the last dose of DMI) in reserpinized mice. 4. Acute DMI administration slightly attenuated the hypothermia and hypoactivity induced by UK-14,304 (0.25-1.0 mg kg-1, i.p.) when injected 2h, but not when injected 18-21h before the agonist. In contrast, 18-21h after withdrawal from chronic DMI both of these responses to UK-14, 304 were markedly attenuated. 5. As the thermogenic response to clonidine in reserpinized mice appears to involve central post-synaptic alpha 2-adrenoceptors, these results suggest that prolonged inhibition of NA uptake decreases the sensitivity of postsynaptic alpha 2-adrenoceptors. The results of the studies using UK-14,304 indicate that central alpha 2-adrenoceptors involved in mediating other behavioural and pharmacological responses to alpha 2-agonists are also down-regulated by chronic inhibition of NA uptake. | lld:pubmed |
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| pubmed-article:2564289 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2564289 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2564289 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2564289 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2564289 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2564289 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2564289 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:2564289 | pubmed:author | pubmed-author:HughesI EIE | lld:pubmed |
| pubmed-article:2564289 | pubmed:author | pubmed-author:StephensR JRJ | lld:pubmed |
| pubmed-article:2564289 | pubmed:author | pubmed-author:BellH BHB | lld:pubmed |
| pubmed-article:2564289 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2564289 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:2564289 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2564289 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2564289 | pubmed:pagination | 144-52 | lld:pubmed |
| pubmed-article:2564289 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2564289 | pubmed:meshHeading | pubmed-meshheading:2564289-... | lld:pubmed |
| pubmed-article:2564289 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2564289 | pubmed:articleTitle | The effects of acute and chronic desipramine on the thermogenic and hypoactivity responses to alpha 2-agonists in reserpinized and normal mice. | lld:pubmed |
| pubmed-article:2564289 | pubmed:affiliation | Wyeth Research (UK) Limited, Maidenhead, Berks. | lld:pubmed |
| pubmed-article:2564289 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2564289 | pubmed:publicationType | Comparative Study | lld:pubmed |
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